KL001
CAS No. 309928-48-1
KL001 ( KL-001;KL 001 )
Catalog No. M13992 CAS No. 309928-48-1
KL001 (KL-001) is a small molecule that specifically interacts with cryptochrome (CRY) and small molecule modulator of the circadian clock.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
5MG | 72 | Get Quote |
|
10MG | 104 | Get Quote |
|
25MG | 178 | Get Quote |
|
50MG | 264 | Get Quote |
|
100MG | 394 | Get Quote |
|
500MG | 885 | Get Quote |
|
1G | Get Quote | Get Quote |
|
Biological Information
-
Product NameKL001
-
NoteResearch use only, not for human use.
-
Brief DescriptionKL001 (KL-001) is a small molecule that specifically interacts with cryptochrome (CRY) and small molecule modulator of the circadian clock.
-
DescriptionKL001 (KL-001) is a small molecule that specifically interacts with cryptochrome (CRY) and small molecule modulator of the circadian clock; prevents SCFFBXL3-mediated ubiquitination and degradation of CRY, resulting in lengthening of the circadian period, interacts directly with CRY1 and CRY2 and stabilizes CRY proteins; KL001-mediated CRY stabilization inhibited glucagon-induced gluconeogenesis in primary hepatocytes; KL001 is the first-in-class cryptochrome-targeting circadian modulator and substrate-targeting ubiquitination antagonist.
-
SynonymsKL-001;KL 001
-
PathwayProteasome/Ubiquitin
-
TargetDUB
-
RecptorDUB
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number309928-48-1
-
Formula Weight398.48
-
Molecular FormulaC21H22N2O4S
-
Purity>98% (HPLC)
-
Solubility——
-
SMILESCS(=O)(N(CC(O)CN1C2=C(C3=C1C=CC=C3)C=CC=C2)CC4=CC=CO4)=O
-
Chemical NameN-[3-(9H-Carbazol-9-yl)-2-hydroxypropyl]-N-(2-furanylmethyl)-methanesulfonamide
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Hirota T, et al. Science. 2012 Aug 31;337(6098):1094-7.
2. Nangle S, et al. Cell Res. 2013 Dec;23(12):1417-9.
3. St John PC, et al. Proc Natl Acad Sci U S A. 2014 Feb 4;111(5):2040-5.
4. Oshima T, et al. Angew Chem Int Ed Engl. 2015 Jun 8;54(24):7193-7.
2. Nangle S, et al. Cell Res. 2013 Dec;23(12):1417-9.
3. St John PC, et al. Proc Natl Acad Sci U S A. 2014 Feb 4;111(5):2040-5.
4. Oshima T, et al. Angew Chem Int Ed Engl. 2015 Jun 8;54(24):7193-7.
molnova catalog
related products
-
B-AP15
B-AP15(NSC687852) is a specific inhibitor of the deubiquitinating enzymes UCHL5 and Usp14 of the 26S proteasome.
-
P 22077
P22077 is an inhibitor of ubiquitin-specific protease USP7 with EC50 of 8.6 μM, also inhibits the closely related USP47.
-
MK8745
MK-8745 is a potent and selective Aurora A inhibitor.