KL001

CAS No. 309928-48-1

KL001 ( KL-001;KL 001 )

Catalog No. M13992 CAS No. 309928-48-1

KL001 (KL-001) is a small molecule that specifically interacts with cryptochrome (CRY) and small molecule modulator of the circadian clock.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 72 Get Quote
10MG 104 Get Quote
25MG 178 Get Quote
50MG 264 Get Quote
100MG 394 Get Quote
500MG 885 Get Quote
1G Get Quote Get Quote

Biological Information

  • Product Name
    KL001
  • Note
    Research use only, not for human use.
  • Brief Description
    KL001 (KL-001) is a small molecule that specifically interacts with cryptochrome (CRY) and small molecule modulator of the circadian clock.
  • Description
    KL001 (KL-001) is a small molecule that specifically interacts with cryptochrome (CRY) and small molecule modulator of the circadian clock; prevents SCFFBXL3-mediated ubiquitination and degradation of CRY, resulting in lengthening of the circadian period, interacts directly with CRY1 and CRY2 and stabilizes CRY proteins; KL001-mediated CRY stabilization inhibited glucagon-induced gluconeogenesis in primary hepatocytes; KL001 is the first-in-class cryptochrome-targeting circadian modulator and substrate-targeting ubiquitination antagonist.
  • Synonyms
    KL-001;KL 001
  • Pathway
    Proteasome/Ubiquitin
  • Target
    DUB
  • Recptor
    DUB
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    309928-48-1
  • Formula Weight
    398.48
  • Molecular Formula
    C21H22N2O4S
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    CS(=O)(N(CC(O)CN1C2=C(C3=C1C=CC=C3)C=CC=C2)CC4=CC=CO4)=O
  • Chemical Name
    N-[3-(9H-Carbazol-9-yl)-2-hydroxypropyl]-N-(2-furanylmethyl)-methanesulfonamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Hirota T, et al. Science. 2012 Aug 31;337(6098):1094-7.
2. Nangle S, et al. Cell Res. 2013 Dec;23(12):1417-9.
3. St John PC, et al. Proc Natl Acad Sci U S A. 2014 Feb 4;111(5):2040-5.
4. Oshima T, et al. Angew Chem Int Ed Engl. 2015 Jun 8;54(24):7193-7.
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