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KL001

CAS No. 309928-48-1

KL001( KL-001 | KL 001 )

Catalog No. M13992 CAS No. 309928-48-1

KL001 (KL-001) is a small molecule that specifically interacts with cryptochrome (CRY) and small molecule modulator of the circadian clock.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    KL001
  • Note
    Research use only, not for human use.
  • Brief Description
    KL001 (KL-001) is a small molecule that specifically interacts with cryptochrome (CRY) and small molecule modulator of the circadian clock.
  • Description
    KL001 (KL-001) is a small molecule that specifically interacts with cryptochrome (CRY) and small molecule modulator of the circadian clock; prevents SCFFBXL3-mediated ubiquitination and degradation of CRY, resulting in lengthening of the circadian period, interacts directly with CRY1 and CRY2 and stabilizes CRY proteins; KL001-mediated CRY stabilization inhibited glucagon-induced gluconeogenesis in primary hepatocytes; KL001 is the first-in-class cryptochrome-targeting circadian modulator and substrate-targeting ubiquitination antagonist.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    KL-001 | KL 001
  • Pathway
    Proteasome/Ubiquitin
  • Target
    DUB
  • Recptor
    DUB
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    309928-48-1
  • Formula Weight
    398.477
  • Molecular Formula
    C21H22N2O4S
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 5 mg/mL (12.55 mM助)
  • SMILES
    CS(=O)(N(CC(O)CN1C2=C(C3=C1C=CC=C3)C=CC=C2)CC4=CC=CO4)=O
  • Chemical Name
    N-[3-(9H-Carbazol-9-yl)-2-hydroxypropyl]-N-(2-furanylmethyl)-methanesulfonamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Hirota T, et al. Science. 2012 Aug 31;337(6098):1094-7. 2. Nangle S, et al. Cell Res. 2013 Dec;23(12):1417-9. 3. St John PC, et al. Proc Natl Acad Sci U S A. 2014 Feb 4;111(5):2040-5. 4. Oshima T, et al. Angew Chem Int Ed Engl. 2015 Jun 8;54(24):7193-7.
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