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GNE-495
CAS No. 1449277-10-4
GNE-495( GNE 495 | GNE495 )
Catalog No. M11931 CAS No. 1449277-10-4
A potent and highly selective, cell permeable MAP4K4 inhibitor with IC50 of 3.7 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 87 | Get Quote |
|
| 10MG | 133 | Get Quote |
|
| 100MG | Get Quote | Get Quote |
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| 200MG | Get Quote | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameGNE-495
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NoteResearch use only, not for human use.
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Brief DescriptionA potent and highly selective, cell permeable MAP4K4 inhibitor with IC50 of 3.7 nM.
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DescriptionA potent and highly selective, cell permeable MAP4K4 inhibitor with IC50 of 3.7 nM; exhibits adequate potency preventing migration of HUVEC cells in vitro (IC50=57 nM); has good PK and demonstrates in vivo efficacy in a retinal angiogenesis model .
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In Vitro——
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In Vivo——
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SynonymsGNE 495 | GNE495
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PathwayMAPK/ERK Signaling
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TargetMAP4K
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RecptorMAP4K
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number1449277-10-4
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Formula Weight405.4249
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Molecular FormulaC22H20FN5O2
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Purity>98% (HPLC)
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SolubilityDMSO: 10 mg/mL
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SMILESO=C(C1=C2C=CC(C3=CC=CC(F)=C3)=NC2=C(N)N=C1)NC4CN(C(C5CC5)=O)C4
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Chemical Name1,7-Naphthyridine-5-carboxamide, 8-amino-N-[1-(cyclopropylcarbonyl)-3-azetidinyl]-2-(3-fluorophenyl)-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Ndubaku CO, et al. ACS Med Chem Lett. 2015 Jun 29;6(8):913-8.
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