
GDC-0152
CAS No. 873652-48-3
GDC-0152( —— )
Catalog No. M16352 CAS No. 873652-48-3
GDC-0152 is a potent antagonist of XIAP-BIR3, ML-IAP-BIR3, cIAP1-BIR3 and cIAP2-BIR3 with Ki of 28 nM, 14 nM, 17 nM and 43 nM, respectively.
Purity : >98% (HPLC)






Size | Price / USD | Stock | Quantity |
2MG | 47 | In Stock |
![]() ![]() |
5MG | 77 | In Stock |
![]() ![]() |
10MG | 113 | In Stock |
![]() ![]() |
25MG | 207 | In Stock |
![]() ![]() |
50MG | 332 | In Stock |
![]() ![]() |
100MG | Get Quote | In Stock |
![]() ![]() |
200MG | Get Quote | In Stock |
![]() ![]() |
500MG | Get Quote | In Stock |
![]() ![]() |
1G | Get Quote | In Stock |
![]() ![]() |
Biological Information
-
Product NameGDC-0152
-
NoteResearch use only, not for human use.
-
Brief DescriptionGDC-0152 is a potent antagonist of XIAP-BIR3, ML-IAP-BIR3, cIAP1-BIR3 and cIAP2-BIR3 with Ki of 28 nM, 14 nM, 17 nM and 43 nM, respectively.
-
DescriptionGDC-0152 is a potent antagonist of XIAP-BIR3, ML-IAP-BIR3, cIAP1-BIR3 and cIAP2-BIR3 with Ki of 28 nM, 14 nM, 17 nM and 43 nM, respectively; less affinity shown to cIAP1-BIR2 and cIAP2-BIR2. Phase 1. (In Vivo):GDC-0152 has moderate predicted hepatic clearance based on metabolic stability assays conducted using human liver microsomes. Plasma?protein binding of GDC-0152 is moderate and comparable among mice (88?91%), rats (89?91%), dogs (81?90%), monkeys (76?85%), and humans (75?83%) over the range of concentrations investigated (0.1?100 μM); higher plasma?protein binding is observed in rabbits (95?96%). GDC-0152 does not preferentially distribute to red blood cells with blood?plasma partition ratios ranging from 0.6 to 1.1 in all species tested. The pharmacokinetics for GDC-0152 is achieved with a C max of 53.7 μM and AUC of 203.5 h·μM.
-
In Vitro——
-
In Vivo——
-
Synonyms——
-
PathwayApoptosis
-
TargetIAP
-
RecptorcIAP1-BIR3| cIAP2-BIR3| MLXBIR3SG| XIAP-BIR2| XIAP-BIR3
-
Research AreaCancer
-
Indication——
Chemical Information
-
CAS Number873652-48-3
-
Formula Weight498.64
-
Molecular FormulaC25H34N6O3S
-
Purity>98% (HPLC)
-
SolubilityDMSO:99 mg/mL (198.54 mM); Ethanol:99 mg/mL (198.54 mM); Water:3 mg/mL (6.01 mM)
-
SMILESCN[C@@H](C)C(=O)N[C@@H](C1CCCCC1)C(=O)N1CCC[C@H]1C(=O)NC1=C(N=NS1)C1=CC=CC=C1 |r,c:28,34,36,t:26,32|
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1.Flygare JA, et al. J Med Chem, 2012, 55(9), 4101-4113.
molnova catalog



related products
-
CS3
CS3 is a potent, selective cIAP1 and cIAP2 inhibitor with IC50 of 16 nM and 85 nM respectively.
-
YM-155
A potent, specific survivin inhibitor that inhibits survivin promoter activity with IC50 of 0.54 nM.
-
UC-112
UC-112 is a novel IAP inhibitor that potently inhibits human melanoma (A375 and M14) and human prostate (PC-3 and DU145) cancer cell lines with IC50 of 0.7-3.4 uM.