
GDC-0152
CAS No. 873652-48-3
GDC-0152( —— )
Catalog No. M16352 CAS No. 873652-48-3
GDC-0152 is a potent antagonist of XIAP-BIR3, ML-IAP-BIR3, cIAP1-BIR3 and cIAP2-BIR3 with Ki of 28 nM, 14 nM, 17 nM and 43 nM, respectively.
Purity : >98% (HPLC)






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2MG | 47 | In Stock |
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5MG | 77 | In Stock |
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10MG | 113 | In Stock |
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25MG | 207 | In Stock |
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50MG | 332 | In Stock |
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100MG | Get Quote | In Stock |
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Biological Information
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Product NameGDC-0152
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NoteResearch use only, not for human use.
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Brief DescriptionGDC-0152 is a potent antagonist of XIAP-BIR3, ML-IAP-BIR3, cIAP1-BIR3 and cIAP2-BIR3 with Ki of 28 nM, 14 nM, 17 nM and 43 nM, respectively.
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DescriptionGDC-0152 is a potent antagonist of XIAP-BIR3, ML-IAP-BIR3, cIAP1-BIR3 and cIAP2-BIR3 with Ki of 28 nM, 14 nM, 17 nM and 43 nM, respectively; less affinity shown to cIAP1-BIR2 and cIAP2-BIR2. Phase 1. (In Vivo):GDC-0152 has moderate predicted hepatic clearance based on metabolic stability assays conducted using human liver microsomes. Plasma?protein binding of GDC-0152 is moderate and comparable among mice (88?91%), rats (89?91%), dogs (81?90%), monkeys (76?85%), and humans (75?83%) over the range of concentrations investigated (0.1?100 μM); higher plasma?protein binding is observed in rabbits (95?96%). GDC-0152 does not preferentially distribute to red blood cells with blood?plasma partition ratios ranging from 0.6 to 1.1 in all species tested. The pharmacokinetics for GDC-0152 is achieved with a C max of 53.7 μM and AUC of 203.5 h·μM.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayApoptosis
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TargetIAP
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RecptorcIAP1-BIR3| cIAP2-BIR3| MLXBIR3SG| XIAP-BIR2| XIAP-BIR3
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number873652-48-3
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Formula Weight498.64
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Molecular FormulaC25H34N6O3S
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Purity>98% (HPLC)
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SolubilityDMSO:99 mg/mL (198.54 mM); Ethanol:99 mg/mL (198.54 mM); Water:3 mg/mL (6.01 mM)
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SMILESCN[C@@H](C)C(=O)N[C@@H](C1CCCCC1)C(=O)N1CCC[C@H]1C(=O)NC1=C(N=NS1)C1=CC=CC=C1 |r,c:28,34,36,t:26,32|
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Flygare JA, et al. J Med Chem, 2012, 55(9), 4101-4113.
molnova catalog



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GDC-0152
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