Cart
sales@molnova.com
YM-155
CAS No. 781661-94-7
YM-155( YM155 | Sepantronium bromide | YM 155 )
Catalog No. M15948 CAS No. 781661-94-7
A potent, specific survivin inhibitor that inhibits survivin promoter activity with IC50 of 0.54 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 30 | In Stock |
|
| 5MG | 45 | In Stock |
|
| 10MG | 65 | In Stock |
|
| 25MG | 136 | In Stock |
|
| 50MG | 243 | In Stock |
|
| 100MG | 397 | In Stock |
|
| 500MG | 882 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameYM-155
-
NoteResearch use only, not for human use.
-
Brief DescriptionA potent, specific survivin inhibitor that inhibits survivin promoter activity with IC50 of 0.54 nM.
-
DescriptionA potent, specific survivin inhibitor that inhibits survivin promoter activity with IC50 of 0.54 nM; does not significantly inhibit SV40 promoter activity (>30 uM); suppresses expression of survivin and induces apoptosis in PC-3 and PPC-1 human HRPC cell lines at 10 nM, without effect on IAP- or Bcl-2-related proteins; induces massive tumor regression in PC-3 tumor mice model (3-10 mg/kg).Blood Cancer Phase 1 Discontinued.
-
In Vitro——
-
In Vivo——
-
SynonymsYM155 | Sepantronium bromide | YM 155
-
PathwayApoptosis
-
TargetIAP
-
RecptorSurvivin
-
Research AreaCancer
-
IndicationBlood cancer
Chemical Information
-
CAS Number781661-94-7
-
Formula Weight443.2939
-
Molecular FormulaC20H19BrN4O3
-
Purity>98% (HPLC)
-
SolubilityDMSO: 10.66 mg/mL
-
SMILESO=C(C1=C2[N+](CCOC)=C(C)N1CC3=NC=CN=C3)C4=C(C=CC=C4)C2=O.[Br-]
-
Chemical Name1H-Naphth[2,3-d]imidazolium, 4,9-dihydro-1-(2-methoxyethyl)-2-methyl-4,9-dioxo-3-(2-pyrazinylmethyl)-, bromide (1:1)
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Nakahara T, et al. Cancer Res. 2007 Sep 1;67(17):8014-21.
2. Iwasa T, et al. Clin Cancer Res. 2008 Oct 15;14(20):6496-504.
3. Satoh T, et al. Clin Cancer Res. 2009 Jun 1;15(11):3872-80.
4. Iwasa T, et al. Br J Cancer. 2010 Jun 29;103(1):36-42.
molnova catalog
related products
-
CS3
CS3 is a potent, selective cIAP1 and cIAP2 inhibitor with IC50 of 16 nM and 85 nM respectively.
-
MV1
A small-molecule IAP antagonist that binds to select baculovirus IAP repeat (BIR) domains resulting in dramatic induction of auto-ubiquitination activity and rapid proteasomal degradation of c-IAPs.
-
YM-155 hydrochloride
A potent, specific survivin inhibitor that inhibits survivin promoter activity with IC50 of 0.54 nM.
