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UC-112

CAS No. 383392-66-3

UC-112( UC112 )

Catalog No. M14330 CAS No. 383392-66-3

UC-112 is a novel IAP inhibitor that potently inhibits human melanoma (A375 and M14) and human prostate (PC-3 and DU145) cancer cell lines with IC50 of 0.7-3.4 uM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    UC-112
  • Note
    Research use only, not for human use.
  • Brief Description
    UC-112 is a novel IAP inhibitor that potently inhibits human melanoma (A375 and M14) and human prostate (PC-3 and DU145) cancer cell lines with IC50 of 0.7-3.4 uM.
  • Description
    UC-112 is a novel IAP inhibitor that potently inhibits human melanoma (A375 and M14) and human prostate (PC-3 and DU145) cancer cell lines with IC50 of 0.7-3.4 uM; also potently inhibits the growth of P-gp-overexpressed multidrug-resistant cancer cells, strongly activates caspase-3/7 and caspase-9 activities, and selectively downregulates survivin level at 1 uM; strongly inhibits tumor growth and reduces both X chromosome-linked IAP and survivin levels in an A375 human melanoma xenograft model in vivo.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    UC112
  • Pathway
    Apoptosis
  • Target
    IAP
  • Recptor
    IAP
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    383392-66-3
  • Formula Weight
    348.4382
  • Molecular Formula
    C22H24N2O2
  • Purity
    >98% (HPLC)
  • Solubility
    10 mM in DMSO
  • SMILES
    OC1=C2N=CC=CC2=C(COCC3=CC=CC=C3)C=C1CN4CCCC4
  • Chemical Name
    8-Quinolinol, 5-[(phenylmethoxy)methyl]-7-(1-pyrrolidinylmethyl)-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Wang J, et al. J Pharmacol Exp Ther. 2014 May;349(2):319-29. 2. Xiao M, et al. PLoS One. 2015 Jun 12;10(6):e0129807.
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