GAT-100 ( GAT100 )

Catalog No. M12537 CAS No. 1663564-42-8

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

GAT-100
Note

Research use only, not for human use.
Brief Description

GAT-100 (GAT100) is a potent, selective CB1R negative allosteric modulator (NAM) with cAMP EC50 and β-arr EC50 of 174 nM and 2.1 nM.
Description

GAT-100 (GAT100) is a potent, selective CB1R negative allosteric modulator (NAM) with cAMP EC50 and β-arr EC50 of 174 nM and 2.1 nM, does not exhibit inverse agonism; GAT-100 is a covalent probe for mapping structure-function correlates characteristic of the druggable CB1R allosteric space.
Synonyms

GAT100
Pathway

GPCR/G Protein
Target

Cannabinoid Receptor
Recptor

Cannabinoid Receptor
Research Area

——
Indication

——

CAS Number

1663564-42-8
Formula Weight

432.59
Molecular Formula

C25H28N4OS
Purity

>98% (HPLC)
Solubility

——
SMILES

O=C(C(N1)=C(CC)C2=C1C=CC(N=C=S)=C2)NCCC3=CC=C(N4CCCCC4)C=C3
Chemical Name

3-Ethyl-5-isothiocyanato-N-(4-(piperidin-1-yl)phenethyl)-1H-indole-2-carboxamide

1. Kulkarni PM, et al. J Med Chem. 2016 Jan 14;59(1):44-60.
2. Laprairie RB, et al. ACS Chem Neurosci. 2016 Jun 15;7(6):776-98.

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