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AM-6538
CAS No. 1245626-00-9
AM-6538( AM6538 | AM 6538 )
Catalog No. M10994 CAS No. 1245626-00-9
AM-6538 (AM6538) is a potent, selective cannabinoid receptor CB1 antagonist with Ki of 5.1 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 336 | Get Quote |
|
| 50MG | 1638 | Get Quote |
|
| 100MG | 2250 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameAM-6538
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NoteResearch use only, not for human use.
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Brief DescriptionAM-6538 (AM6538) is a potent, selective cannabinoid receptor CB1 antagonist with Ki of 5.1 nM.
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DescriptionAM-6538 (AM6538) is a potent, selective cannabinoid receptor CB1 antagonist with Ki of 5.1 nM.
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In VitroAM6538 is a cannabinoid antagonist that binds CB1 receptors expressed in HEK-293 cells in a wash-resistant manner.
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In VivoAM6538 (1~10 mg/kg) antagonizes the antinociceptive effects of cannabinoid agonists in mice.AM6538 (10 mg/kg) shows that there are some recovery in the effects of AM4054. AM6538 dose dependently decreases the tau values for all cannabinoid agonists, reflecting reductions in the available receptors. AM6538 produces enduring antagonism, with robust effects on the tetrahydrocannabinol dose-effect function evident up to 7 days after treatment.
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SynonymsAM6538 | AM 6538
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PathwayGPCR/G Protein
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TargetCannabinoid Receptor
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RecptorCannabinoid Receptor
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Research Area——
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Indication——
Chemical Information
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CAS Number1245626-00-9
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Formula Weight542.417
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Molecular FormulaC26H25Cl2N5O4
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 180 mg/mL (331.85 mM)
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SMILESO=[N+]([O-])OCCC#CC1=CC=C(C2=C(C)C(C(NN3CCCCC3)=O)=NN2C4=CC=C(Cl)C(Cl)=C4)C=C1
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Chemical Name4-(4-(1-(2,4-dichlorophenyl)-4-methyl-3-(piperidin-1-ylcarbamoyl)-1H-pyrazol-5-yl)phenyl)but-3-yn-1-yl nitrate
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Hua T, et al. Cell. 2016 Oct 20;167(3):750-762.e14.
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