Cart
sales@molnova.com
NESS-0327
CAS No. 494844-07-4
NESS-0327 ( NESS 0327;NESS0327 )
Catalog No. M14656 CAS No. 494844-07-4
A potent, selective CB1 cannabinoid receptor antagonist with Ki of 350 fM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 484 | Get Quote |
|
| 10MG | 691 | Get Quote |
|
| 25MG | 1035 | Get Quote |
|
| 50MG | 1395 | Get Quote |
|
| 100MG | 1872 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
-
Product NameNESS-0327
-
NoteResearch use only, not for human use.
-
Brief DescriptionA potent, selective CB1 cannabinoid receptor antagonist with Ki of 350 fM.
-
DescriptionA potent, selective CB1 cannabinoid receptor antagonist with Ki of 350 fM, >60,000-fold selective for the CB1 receptor versus CB2 receptor (Ki=21 nM); antagonizes WIN 55,212-2-stimulated [35S]GTPgammaS binding, antagonizes the inhibitory effects of WIN 55,212-2 on electrically evoked contractions in mouse isolated vas deferens preparations with pA2 12.46; inhibits the antinociceptive effect produced by WIN 55,212-2 (2 mg/kg s.c.) in both tail-flick (ID50=0.042 mg/kg i.p.) and hot-plate test (ID50=0.018 mg/kg i.p.).
-
SynonymsNESS 0327;NESS0327
-
PathwayGPCR/G Protein
-
TargetCannabinoid Receptor
-
RecptorCannabinoid Receptor
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number494844-07-4
-
Formula Weight489.80
-
Molecular FormulaC24H23Cl3N4O
-
Purity>98% (HPLC)
-
Solubility——
-
SMILESO=C(C1=NN(C2=CC=C(Cl)C=C2Cl)C3=C1CCCC4=CC(Cl)=CC=C43)NN5CCCCC5
-
Chemical NameN-piperidinyl-[8-chloro-1-(2,4-dichlorophenyl)-1,4,5,6-tetrahydrobenzo [6,7]cyclohepta[1,2-c]pyrazole-3-carboxamide
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Ruiu S, et al. J Pharmacol Exp Ther. 2003 Jul;306(1):363-70.
2. Tambaro S, et al. Eur J Pharmacol. 2005 Nov 21;525(1-3):150-3.
3. Murineddu G, et al. J Med Chem. 2005 Nov 17;48(23):7351-62.
2. Tambaro S, et al. Eur J Pharmacol. 2005 Nov 21;525(1-3):150-3.
3. Murineddu G, et al. J Med Chem. 2005 Nov 17;48(23):7351-62.
molnova catalog
related products
-
Repertaxin
Reparixin is a potent inhibitor of both CXCL8 receptorsCXCR1/2, it inhibits weaklyCXCR2-mediated cell migration (IC50=100 nM), whereas it strongly blocksCXCR1-mediated chemotaxis (IC50=1 nM).
-
VCE-004.3
VCE-004.3 (VCE004.3) is a novel semi-synthetic cannabidiol derivative behaving as a dual PPARγ/CB2 agonist and CB1 receptor modulator.
-
RVD-Hpα
N-terminally extended form of human hemopressin that acts as a selective CB1 receptor agonist. Increases intracellular Ca2+ levels in cells expressing CB1 receptors in vitro. Also high affinity CB2 positive allosteric modulator (Ki = 50 nM).
