G907 ( G-907;G 907 )

Catalog No. M17102 CAS No.

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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Product Name

G907
Note

Research use only, not for human use.
Brief Description

G907 is a potent, selective small-molecule antagonist of ATP-binding cassette (ABC) transporter MsbA with IC50 of 18 nM.
Description

G907 is a potent, selective small-molecule antagonist of ATP-binding cassette (ABC) transporter MsbA with IC50 of 18 nM; traps MsbA in an inward-facing, lipopolysaccharide-bound conformation by wedging into an architecturally conserved transmembrane pocket, inhibits the growth of wild-type E. coli and Klebsiella pneumoniae with MIC of 5.6 ug/ml.
Synonyms

G-907;G 907
Pathway

GPCR/G Protein
Target

Antibacterial
Recptor

Antibacterial
Research Area

——
Indication

——

CAS Number

--
Formula Weight

433.93
Molecular Formula

C26H24ClNO3
Purity

>98% (HPLC)
Solubility

——
SMILES

O=C(O)/C=C/C1=C(C2CC2)C3=CC(OC(C4=C(C5CC5)C=CC=C4Cl)C)=CC=C3N=C1
Chemical Name

(E)-3-(6-(1-(2-chloro-6-cyclopropylphenyl)ethoxy)-4-cyclopropylquinolin-3-yl)acrylic acid

1. Ho H, et al. Nature. 2018 May 2. doi: 10.1038/s41586-018-0083-5.

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