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G907
CAS No.
G907 ( G-907;G 907 )
Catalog No. M17102 CAS No.
G907 is a potent, selective small-molecule antagonist of ATP-binding cassette (ABC) transporter MsbA with IC50 of 18 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameG907
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NoteResearch use only, not for human use.
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Brief DescriptionG907 is a potent, selective small-molecule antagonist of ATP-binding cassette (ABC) transporter MsbA with IC50 of 18 nM.
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DescriptionG907 is a potent, selective small-molecule antagonist of ATP-binding cassette (ABC) transporter MsbA with IC50 of 18 nM; traps MsbA in an inward-facing, lipopolysaccharide-bound conformation by wedging into an architecturally conserved transmembrane pocket, inhibits the growth of wild-type E. coli and Klebsiella pneumoniae with MIC of 5.6 ug/ml.
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SynonymsG-907;G 907
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PathwayGPCR/G Protein
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TargetAntibacterial
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RecptorAntibacterial
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Research Area——
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Indication——
Chemical Information
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CAS Number--
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Formula Weight433.93
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Molecular FormulaC26H24ClNO3
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Purity>98% (HPLC)
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Solubility——
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SMILESO=C(O)/C=C/C1=C(C2CC2)C3=CC(OC(C4=C(C5CC5)C=CC=C4Cl)C)=CC=C3N=C1
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Chemical Name(E)-3-(6-(1-(2-chloro-6-cyclopropylphenyl)ethoxy)-4-cyclopropylquinolin-3-yl)acrylic acid
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Ho H, et al. Nature. 2018 May 2. doi: 10.1038/s41586-018-0083-5.
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