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TBA-354

CAS No. 1257426-19-9

TBA-354 ( TBA354 )

Catalog No. M11059 CAS No. 1257426-19-9

TBA-354 is a novel antitubercular agent that shows MIC of 6 uM against M. tuberculosis H37Rv.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    TBA-354
  • Note
    Research use only, not for human use.
  • Brief Description
    TBA-354 is a novel antitubercular agent that shows MIC of 6 uM against M. tuberculosis H37Rv.
  • Description
    TBA-354 is a novel antitubercular agent that shows MIC of 6 uM against M. tuberculosis H37Rv; maintains activity against Mycobacterium tuberculosis H37Rv isogenic monoresistant strains and clinical drug-sensitive and drug-resistant isolates, demonstrates superior potency and pharmacokinetic profile compared with PA-824, 5 to 10 times more potent than PA-824.Bacterial Infection Phase 1 Clinical
  • Synonyms
    TBA354
  • Pathway
    GPCR/G Protein
  • Target
    Antibacterial
  • Recptor
    Others
  • Research Area
    Infection
  • Indication
    Bacterial Infection

Chemical Information

  • CAS Number
    1257426-19-9
  • Formula Weight
    436.34
  • Molecular Formula
    C19H15F3N4O5
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: ≥ 46 mg/mL
  • SMILES
    O=[N+](C1=CN2C(OC[C@@H](OCC3=CC=C(C4=CC=C(OC(F)(F)F)C=C4)N=C3)C2)=N1)[O-]
  • Chemical Name
    5H-Imidazo[2,1-b][1,3]oxazine, 6,7-dihydro-2-nitro-6-[[6-[4-(trifluoromethoxy)phenyl]-3-pyridinyl]methoxy]-, (6S)-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Kmentova I, et al. J Med Chem. 2010 Dec 9;53(23):8421-39.
2. Upton AM, et al. Antimicrob Agents Chemother. 2015 Jan;59(1):136-44.
3. Tasneen R, et al. Antimicrob Agents Chemother. 2015 Jan;59(1):129-35.
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