Floxuridine( 5-FDU | 5-Fluorodeoxyuridine | NSC 26740 | NSC 27640 )

Catalog No. M14750 CAS No. 50-91-9

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

Floxuridine
Note

Research use only, not for human use.
Brief Description

Floxuridine (5-fluorodeoxyuridine) is an oncology drug that belongs to the class known as antimetabolites with an GI50 of 5.1 μM for the inhibition of PEPT1.
Description

Floxuridine (5-fluorodeoxyuridine) is an oncology drug that belongs to the class known as antimetabolites with an GI50 of 5.1 μM for the inhibition of PEPT1.
In Vitro

Cell Viability Assay Cell Line:Ovarian cancer cells Concentration:0-25 μM Incubation Time: 4, 8, 24 hours Result:Was potentiated the sensitivity by ?PARP inhibitors.Western Blot Analysis Cell Line:OVCAR-8 and SKOV3ip cells Concentration:300 μM Incubation Time: 4, 8, 24 hours Result:Induced phosphorylation of Chk1 and Chk2 in two ovarian cancer cell lines Cell Cycle Analysis Cell Line:A2780, SKOV3ip, OVCAR-5, and OVCAR-3 ovarian cancer cells Concentration:0.5, 1.0, 1.5, 2.0, and 2.5 μM Incubation Time:24 hours Result:Induced cell arrest at G1/S-phase period.
In Vivo

Animal Model:C57BL/6 mice injected with?S. aureus Dosage:0.5-1.25 mg/kg Administration:once per day for 7 days or single dose Result:Was a very potent inhibitor for S. aureus infection in vivo.
Synonyms

5-FDU | 5-Fluorodeoxyuridine | NSC 26740 | NSC 27640
Pathway

Cell Cycle/DNA Damage
Target

DNA/RNA Synthesis
Recptor

Thymidylate synthase
Research Area

Cancer
Indication

——

CAS Number

50-91-9
Formula Weight

246.19
Molecular Formula

C9H11FN2O5
Purity

>98% (HPLC)
Solubility

Ethanol: 10 mg/mL (40.61 mM); Water: 49 mg/mL (199.03 mM); DMSO: 49 mg/mL (199.03 mM)
SMILES

O=C1NC(C(F)=CN1[C@@H]2O[C@H](CO)[C@@H](O)C2)=O
Chemical Name

5-fluoro-1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione

1. Ferguson PJ, et al. Br J Pharmacol. 1999 Aug; 127(8):1777-86.

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