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Home - Products - Cell Cycle/DNA Damage - DNA/RNA Synthesis - TFMB-(S)-2-HG

TFMB-(S)-2-HG

CAS No. 1445703-64-9

TFMB-(S)-2-HG( —— )

Catalog No. M34038 CAS No. 1445703-64-9

TFMB-(S)-2-HG (TFMB S 2 HG) is a highly effective inhibitor of TET2, the 5'-methylcytosine hydroxylase. Additionally, it significantly inhibits the EglN prolyl hydroxylases.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 46 Get Quote
10MG 72 Get Quote
25MG 144 Get Quote
50MG 233 Get Quote
100MG 338 Get Quote
500MG 714 Get Quote
1G Get Quote Get Quote
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Biological Information

  • Product Name
    TFMB-(S)-2-HG
  • Note
    Research use only, not for human use.
  • Brief Description
    TFMB-(S)-2-HG (TFMB S 2 HG) is a highly effective inhibitor of TET2, the 5'-methylcytosine hydroxylase. Additionally, it significantly inhibits the EglN prolyl hydroxylases.
  • Description
    TFMB-(S)-2-HG is a potent inhibitor of the 5'-methylcytosine hydroxylase TET2. TFMB-(S)-2-HG also inhibits the EglN prolyl hydroxylases. TFMB-(S)-2-HG has the potential for the research of acute myeloid leukemia (AML).
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    DNA/RNA Synthesis
  • Recptor
    DNA Methyltransferase
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1445703-64-9
  • Formula Weight
    288.22
  • Molecular Formula
    C13H11F3O4
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (346.96 mM; Ultrasonic )
  • SMILES
    FC(F)(F)c1cccc(COC(=O)[C@@H]2CCC(=O)O2)c1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Losman JA, et al. (R)-2-hydroxyglutarate is sufficient to promote leukemogenesis and its effects are reversible. Science. 2013;339(6127):1621-1625.?
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