Fenoterol

Research use only, not for human use.

Fenoterol is an ?agonist of ?β2-adrenergic receptor?It is classed as sympathomimetic beta agonist and asthma medication.

Fenoterol is an ?agonist of ?β2-adrenergic receptor?It is classed as sympathomimetic beta agonist and asthma medication.(In Vitro):Fenoterol (1 μM; pre-incubated 30 minutes) treatment reduces AICAR-induced AMPK activation, NF-κB activation and TNF-α release, and also significantly downregulates the elevated phosphorylation levels of AMPK.Fenoterol inhibits lipopolysaccharide (LPS)-induced AMPK activation and inflammatory cytokine production in THP-1 cells.Fenoterol is also a potent exosome biogenesis and/or secretion activator in PC cells.(In Vivo):Fenoterol (0.7 mg/kg; intraperitoneal injection; twice a day; for 3 weeks) treatment suppresses mechanical allodynia during chronic treatment.

Fenoterol (1 μM; pre-incubated 30 minutes) treatment reduces AICAR-induced AMPK activation, NF-κB activation and TNF-α release, and also significantly downregulates the elevated phosphorylation levels of AMPK.Fenoterol inhibits lipopolysaccharide (LPS)-induced AMPK activation and inflammatory cytokine production in THP-1 cells.Fenoterol is also a potent exosome biogenesis and/or secretion activator in PC cells. Western Blot Analysis Cell Line:THP-1 cells stimulated with AICAR Concentration:1 μM Incubation Time:Pre-incubated 30 minutes Result:Significantly downregulated the elevated phosphorylation levels of AMPK.

Fenoterol (0.7 mg/kg; intraperitoneal injection; twice a day; for 3 weeks) treatment suppresses mechanical allodynia during chronic treatment. Animal Model:Male C57BL/6J mice (6 weeks old) with neuropathy Dosage:0.7 mg/kg Administration:Intraperitoneal injection; twice a day; for 3 weeks Result:Alleviated neuropathic allodynia during chronic treatment.

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Angiogenesis

Adrenergic Receptor

β2-adrenergic receptor

Cardiovascular Disease

Congestive Heart Failure

13392-18-2

303.35

C17H21NO4

>98% (HPLC)

DMSO:61 mg/mL (201.08 mM)

CC(Cc1ccc(O)cc1)NCC(O)c1cc(O)cc(O)c1

5-[1-hydroxy-2-[1-(4-hydroxyphenyl)propan-2-ylamino]ethyl]benzene-13-diol

(-20℃)

With Ice Pack

≥ 2 years