FT-671
CAS No. 1959551-26-8
FT-671 ( FT671;FT 671 )
Catalog No. M13072 CAS No. 1959551-26-8
FT-671 is a novel potent, specific, non-covalent USP7 inhibitor with Kd of 65 nM (USP7 catalytic domain).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
5MG | 1233 | Get Quote |
|
50MG | 2502 | Get Quote |
|
100MG | 3330 | Get Quote |
|
200MG | Get Quote | Get Quote |
|
500MG | Get Quote | Get Quote |
|
1G | Get Quote | Get Quote |
|
Biological Information
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Product NameFT-671
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NoteResearch use only, not for human use.
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Brief DescriptionFT-671 is a novel potent, specific, non-covalent USP7 inhibitor with Kd of 65 nM (USP7 catalytic domain).
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DescriptionFT-671 is a novel potent, specific, non-covalent USP7 inhibitor with Kd of 65 nM (USP7 catalytic domain); inhibits USP7 with IC50 values of 52 nM (USP7 CD) and 69 nM (USP7C-term), display good USP7 selectivity in a panel of 38 deubiquitinases (DUBs); destabilizes USP7 substrates including MDM2, increases levels of p53, and results in the transcription of p53 target genes and induces tumour suppressor p21; blocks the proliferation of MM.1S cells (IC50=33 nM), suppresses tumour growth in mice; orally available.
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SynonymsFT671;FT 671
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PathwayProteasome/Ubiquitin
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TargetDUB
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RecptorDUB
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number1959551-26-8
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Formula Weight533.49
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Molecular FormulaC24H23F4N7O3
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Purity>98% (HPLC)
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Solubility——
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SMILESO=C1C2=C(N=CN1CC3(CCN(CC3)C(C[C@@H](C(F)F)N4N=C(C=C4)F)=O)O)N(N=C2)C5=CC=C(C=C5)F
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Chemical Name(S)-5-((1-(4,4-difluoro-3-(3-fluoro-1H-pyrazol-1-yl)butanoyl)-4-hydroxypiperidin-4-yl)methyl)-1-(4-fluorophenyl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Turnbull AP, et al. Nature. 2017 Oct 26;550(7677):481-486.
molnova catalog
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