P-50429
CAS No. 1247825-37-1
P-50429 ( P50429;P 50429 )
Catalog No. M11001 CAS No. 1247825-37-1
P-50429 (P50429, P 50429) is a potent, selective, covalent deubiquitinase USP7 (EC50=0.42 uM)/USP47 (EC50=1.0 uM) inhibitor.
Purity : 98.80% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
2MG | 171 | In Stock |
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5MG | 312 | In Stock |
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10MG | 447 | In Stock |
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25MG | 714 | In Stock |
|
50MG | 1017 | In Stock |
|
100MG | 1368 | In Stock |
|
500MG | 2673 | In Stock |
|
1G | Get Quote | In Stock |
|
Biological Information
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Product NameP-50429
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NoteResearch use only, not for human use.
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Brief DescriptionP-50429 (P50429, P 50429) is a potent, selective, covalent deubiquitinase USP7 (EC50=0.42 uM)/USP47 (EC50=1.0 uM) inhibitor.
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DescriptionP-50429 (P50429, P 50429) is a potent, selective, covalent deubiquitinase USP7 (EC50=0.42 uM)/USP47 (EC50=1.0 uM) inhibitor with no inhibition for caspase 3, calpain 1, 20S proteasome and a panel of representative USPs; exhibits 20-fold more potent inhibition of USP7 compared with P22077 (IC50 0.42 versus 8.0 uM); destabilizes HDM2, increases p53 and the downstream target p21, inhibits the proliferation of HCT-116 cells.
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SynonymsP50429;P 50429
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PathwayProteasome/Ubiquitin
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TargetDUB
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RecptorUSP7;USP47
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number1247825-37-1
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Formula Weight484.40
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Molecular FormulaC18H11Cl2N3O3S3
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Purity98.80% (HPLC)
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SolubilityDMSO: ≥ 44 mg/mL
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SMILESO/C(C1=CC(C#N)=C(SC2=C(Cl)C=NC=C2Cl)S1)=N\C3=CC=C(S(=O)(C)=O)C=C3
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Chemical Name2-Thiophenecarboxamide, 4-cyano-5-[(3,5-dichloro-4-pyridinyl)thio]-N-[4-(methylsulfonyl)phenyl]-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Weinstock J, et al. ACS Med Chem Lett. 2012 Sep 11;3(10):789-92.
2. Pozhidaeva A, et al. Cell Chem Biol. 2017 Oct 4. pii: S2451-9456(17)30330-6.
2. Pozhidaeva A, et al. Cell Chem Biol. 2017 Oct 4. pii: S2451-9456(17)30330-6.
molnova catalog
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