P-50429

CAS No. 1247825-37-1

P-50429 ( P50429;P 50429 )

Catalog No. M11001 CAS No. 1247825-37-1

P-50429 (P50429, P 50429) is a potent, selective, covalent deubiquitinase USP7 (EC50=0.42 uM)/USP47 (EC50=1.0 uM) inhibitor.

Purity : 98.80% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 171 In Stock
5MG 312 In Stock
10MG 447 In Stock
25MG 714 In Stock
50MG 1017 In Stock
100MG 1368 In Stock
500MG 2673 In Stock
1G Get Quote In Stock

Biological Information

  • Product Name
    P-50429
  • Note
    Research use only, not for human use.
  • Brief Description
    P-50429 (P50429, P 50429) is a potent, selective, covalent deubiquitinase USP7 (EC50=0.42 uM)/USP47 (EC50=1.0 uM) inhibitor.
  • Description
    P-50429 (P50429, P 50429) is a potent, selective, covalent deubiquitinase USP7 (EC50=0.42 uM)/USP47 (EC50=1.0 uM) inhibitor with no inhibition for caspase 3, calpain 1, 20S proteasome and a panel of representative USPs; exhibits 20-fold more potent inhibition of USP7 compared with P22077 (IC50 0.42 versus 8.0 uM); destabilizes HDM2, increases p53 and the downstream target p21, inhibits the proliferation of HCT-116 cells.
  • Synonyms
    P50429;P 50429
  • Pathway
    Proteasome/Ubiquitin
  • Target
    DUB
  • Recptor
    USP7;USP47
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    1247825-37-1
  • Formula Weight
    484.40
  • Molecular Formula
    C18H11Cl2N3O3S3
  • Purity
    98.80% (HPLC)
  • Solubility
    DMSO: ≥ 44 mg/mL
  • SMILES
    O/C(C1=CC(C#N)=C(SC2=C(Cl)C=NC=C2Cl)S1)=N\C3=CC=C(S(=O)(C)=O)C=C3
  • Chemical Name
    2-Thiophenecarboxamide, 4-cyano-5-[(3,5-dichloro-4-pyridinyl)thio]-N-[4-(methylsulfonyl)phenyl]-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Weinstock J, et al. ACS Med Chem Lett. 2012 Sep 11;3(10):789-92.
2. Pozhidaeva A, et al. Cell Chem Biol. 2017 Oct 4. pii: S2451-9456(17)30330-6.
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