Sal003

Research use only, not for human use.

Sal003, an effective cell-permeable analog, inhibitis the eIF2α phosphatase.

SAL-003 is a cell-permeable inhibitor of eIF2α dephosphorylation. SAL003 is an Analog of salubrinal (Cat. No. 2347) with improved aqueous solubility. Sal003?mediated upregulation of eIF2α phosphorylation suppressed cisplatin?induced p53 activation. Furthermore, reduction of eIF2α phosphorylation by PERK knockdown enhanced cisplatin-induced p53 activation and apoptosis.

Apoptosis Analysis Cell Line:HeLa cells Concentration:10 μM Incubation Time:1 hour Result:Phosphorylated eIF2α and thus enhanced SubAB-induced apoptotic signaling.Western Blot Analysis Cell Line:Mouse embryonic fibroblasts (MEFs)Concentration:20 μM Incubation Time:1 hour, 3 hours, 6 hours, 12 hours Result:Sharply increased eIF2α phosphorylation in mouse MEFs.

Animal Model:Rats (300-325g)Dosage:20 μM Administration:Intrahippocampal injection; 8 minutes Result:Impaired contextual memory.

SAL-003 | SAL 003 | SAL003

GPCR/G Protein

Calcium Channel

eIF-2α phosphatase

Cancer

——

1164470-53-4

463.21

C18H15Cl4N3OS

>98% (HPLC)

DMSO : ≥ 100 mg/mL 215.88 mM

c1ccc(cc1)/C=C/C(=O)NC(C(Cl)(Cl)Cl)NC(=S)Nc1ccc(cc1)Cl

3--Phenyl-N-(2,2,2-trichloro-1-((((4-chlorophenyl)amino)carbonothioyl)amino)ethyl)acrylamide

(-20℃)

With Ice Pack

≥ 2 years