Cart
sales@molnova.com
FN1-8
CAS No. 1419258-63-1
FN1-8( Gli inhibitor FN1-8 )
Catalog No. M11753 CAS No. 1419258-63-1
A novel, synthetic small molecule that efficiently interferes with Gli/TAF9 interaction and downregulate Gli/TAF9-dependent transcriptional activity (at 15 uM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 100MG | Get Quote | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
-
Product NameFN1-8
-
NoteResearch use only, not for human use.
-
Brief DescriptionA novel, synthetic small molecule that efficiently interferes with Gli/TAF9 interaction and downregulate Gli/TAF9-dependent transcriptional activity (at 15 uM).
-
DescriptionA novel, synthetic small molecule that efficiently interferes with Gli/TAF9 interaction and downregulate Gli/TAF9-dependent transcriptional activity (at 15 uM); inhibits non-canonical Gli activation and acts downstream of the canonical Hh pathway; suppresses cancer cell proliferation in vitro and inhibits tumor growth in vivo.
-
In Vitro——
-
In Vivo——
-
SynonymsGli inhibitor FN1-8
-
PathwayWnt/Notch/Hedgehog
-
TargetGli
-
RecptorGli
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number1419258-63-1
-
Formula Weight447.538
-
Molecular FormulaC29H25N3O2
-
Purity>98% (HPLC)
-
Solubility——
-
SMILES——
-
Chemical NameN-(4-hydroxybenzyl)-1,3,5-triphenyl-4,5-dihydro-1H-pyrazole-4-carboxamide
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Bosco-Clément G, et al. Oncogene. 2014 Apr 17;33(16):2087-97.
2. He B, et al. US Patent No. 7714014. 2010
molnova catalog
related products
-
Hedgehog-IN-7d
Hedgehog-IN-7d is a potent, cell-permeable Hedgehog (Hh) pathway inhibitor that inhibits Gli transcription activity with an IC50 value of 70 nM.
-
GANT 58
GANT 58 (NSC 75503) is a potent Gli antagonist and Hedgehog signaling (Hh) inhibitor that inhibits GLI1-induced transcription with IC50 of 5 uM.
-
JK184
JK184 is an ntagonist of the hedgehog (Hh) signaling pathway and Gli inhibitor.
