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FIT-039

CAS No. 1113044-49-7

FIT-039 ( FIT039 )

Catalog No. M10417 CAS No. 1113044-49-7

FIT-039 is a potent, selective CDK9 inhibitor with IC50 of 5.8 uM for CKD9/cyclin T1, suppresses the replication of HSV-1 (IC50=0.69 uM)

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    FIT-039
  • Note
    Research use only, not for human use.
  • Brief Description
    FIT-039 is a potent, selective CDK9 inhibitor with IC50 of 5.8 uM for CKD9/cyclin T1, suppresses the replication of HSV-1 (IC50=0.69 uM)
  • Description
    FIT-039 is a potent, selective CDK9 inhibitor with IC50 of 5.8 uM for CKD9/cyclin T1, suppresses the replication of HSV-1 (IC50=0.69 uM); shows no marked inhibitory effect on CDK4/cyclinD3, does not inhibit other CDKs, including CDK2/cyclinB1, CDK2/cyclinE1, CDK5/p25, CDK6/cyclinD3, or CDK7/cyclinH/MAT; suppresses viral replication without affecting the host cell cycle, inhibits viral transcription; also inhibits HBV propagation and HIV-1 replication; suppresses HPV viral oncogenes E6 and E7, and shows therapeutic rffect on HPV-induced neoplasia in vivo.HPV Infection Phase 2 Clinical
  • Synonyms
    FIT039
  • Pathway
    Angiogenesis
  • Target
    CDK
  • Recptor
    CDK
  • Research Area
    Infection
  • Indication
    HPV Infection

Chemical Information

  • CAS Number
    1113044-49-7
  • Formula Weight
    315.41
  • Molecular Formula
    C17H18FN3S
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    C1CCN(CC1)C2=C(C=C(C=C2)F)NC(=S)C3=CC=NC=C3
  • Chemical Name
    N-[5-Fluoro-2-(1-piperidinyl)phenyl]-4-pyridinecarbothioamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Yamamoto M, et al. J Clin Invest. 2014 Aug;124(8):3479-88.
2. Okamoto M, et al. Antiviral Res. 2015 Nov;123:1-4.
3. Tanaka T, et al. Antiviral Res. 2016 Sep;133:156-64.
4. Ajiro M, et al. Clin Cancer Res. 2018 Apr 30. pii: clincanres.3119.2017.
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