FIT-039
CAS No. 1113044-49-7
FIT-039 ( FIT039 )
Catalog No. M10417 CAS No. 1113044-49-7
FIT-039 is a potent, selective CDK9 inhibitor with IC50 of 5.8 uM for CKD9/cyclin T1, suppresses the replication of HSV-1 (IC50=0.69 uM)
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
5MG | 46 | Get Quote |
|
10MG | 76 | Get Quote |
|
25MG | 155 | Get Quote |
|
50MG | 250 | Get Quote |
|
100MG | 376 | Get Quote |
|
500MG | 889 | Get Quote |
|
1G | Get Quote | Get Quote |
|
Biological Information
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Product NameFIT-039
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NoteResearch use only, not for human use.
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Brief DescriptionFIT-039 is a potent, selective CDK9 inhibitor with IC50 of 5.8 uM for CKD9/cyclin T1, suppresses the replication of HSV-1 (IC50=0.69 uM)
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DescriptionFIT-039 is a potent, selective CDK9 inhibitor with IC50 of 5.8 uM for CKD9/cyclin T1, suppresses the replication of HSV-1 (IC50=0.69 uM); shows no marked inhibitory effect on CDK4/cyclinD3, does not inhibit other CDKs, including CDK2/cyclinB1, CDK2/cyclinE1, CDK5/p25, CDK6/cyclinD3, or CDK7/cyclinH/MAT; suppresses viral replication without affecting the host cell cycle, inhibits viral transcription; also inhibits HBV propagation and HIV-1 replication; suppresses HPV viral oncogenes E6 and E7, and shows therapeutic rffect on HPV-induced neoplasia in vivo.HPV Infection Phase 2 Clinical
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SynonymsFIT039
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PathwayAngiogenesis
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TargetCDK
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RecptorCDK
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Research AreaInfection
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IndicationHPV Infection
Chemical Information
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CAS Number1113044-49-7
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Formula Weight315.41
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Molecular FormulaC17H18FN3S
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Purity>98% (HPLC)
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Solubility——
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SMILESC1CCN(CC1)C2=C(C=C(C=C2)F)NC(=S)C3=CC=NC=C3
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Chemical NameN-[5-Fluoro-2-(1-piperidinyl)phenyl]-4-pyridinecarbothioamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Yamamoto M, et al. J Clin Invest. 2014 Aug;124(8):3479-88.
2. Okamoto M, et al. Antiviral Res. 2015 Nov;123:1-4.
3. Tanaka T, et al. Antiviral Res. 2016 Sep;133:156-64.
4. Ajiro M, et al. Clin Cancer Res. 2018 Apr 30. pii: clincanres.3119.2017.
2. Okamoto M, et al. Antiviral Res. 2015 Nov;123:1-4.
3. Tanaka T, et al. Antiviral Res. 2016 Sep;133:156-64.
4. Ajiro M, et al. Clin Cancer Res. 2018 Apr 30. pii: clincanres.3119.2017.
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