Tenovin-D3( Tenovin D3 )

Catalog No. M11063 CAS No. 1258283-70-3

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Product Name

Tenovin-D3
Note

Research use only, not for human use.
Brief Description

A novel selective, small-molecule inhibitor of sirtuin SITR2 with IC50 of 21.8 uM.
Description

A novel selective, small-molecule inhibitor of sirtuin SITR2 with IC50 of 21.8 uM; shows much weaker actvity for SIRT1 (IC50>90 uM), SIRT3 and HDAC8; promotes expression of the cell-cycle regulator and p53 target p21(WAF1/CIP1) (CDKN1A) in a p53-independent manner, fails to increase p53 levels or transcription factor activity.
In Vitro

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In Vivo

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Synonyms

Tenovin D3
Pathway

Chromatin/Epigenetic
Target

Sirtuin
Recptor

Sirtuin
Research Area

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Indication

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CAS Number

1258283-70-3
Formula Weight

533.893
Molecular Formula

C22H27Cl3N4O3S
Purity

>98% (HPLC)
Solubility

——
SMILES

O=C(NC(NC1=CC=C(NC(CCCCN(C)C)=O)C=C1)=S)C2=CC(Cl)=C(OC)C(Cl)=C2.[H]Cl
Chemical Name

3,5-dichloro-N-((4-(5-(dimethylamino)pentanamido)phenyl)carbamothioyl)-4-methoxybenzamide hydrochloride

1. McCarthy AR, et al. Mol Cancer Ther. 2013 Apr;12(4):352-60. 2. Liu R, et al. Sci Rep. 2015 Feb 12;5:8415.

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