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Home - Products - GPCR/G Protein - Chemokine Receptor - FC131

FC131

CAS No. 606968-52-9

FC131( FC 131 | cyclo(-D-Tyr-Arg-Arg-Nal-Gly- )

Catalog No. M15275 CAS No. 606968-52-9

FC131 (cyclo(-D-Tyr-Arg-Arg-Nal-Gly-)) is a selective, cyclopentapeptide CXCR4 antagonist with IC50 of 126 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    FC131
  • Note
    Research use only, not for human use.
  • Brief Description
    FC131 (cyclo(-D-Tyr-Arg-Arg-Nal-Gly-)) is a selective, cyclopentapeptide CXCR4 antagonist with IC50 of 126 nM.
  • Description
    FC131 (cyclo(-D-Tyr-Arg-Arg-Nal-Gly-)) is a selective, cyclopentapeptide CXCR4 antagonist with IC50 of 126 nM, exhibits anti-HIV activity in assays using NL4-3 and IIIB strains with EC50 of 21 nM.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    FC 131 | cyclo(-D-Tyr-Arg-Arg-Nal-Gly-
  • Pathway
    GPCR/G Protein
  • Target
    Chemokine Receptor
  • Recptor
    Chemokine Receptor
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    606968-52-9
  • Formula Weight
    729.84
  • Molecular Formula
    C36H47N11O6
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    O=C(NCC(N[C@@H]1CC2=CC=C(O)C=C2)=O)[C@@H](NC([C@@H](NC([C@@H](NC1=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)CC3=CC(C=CC=C4)=C4C=C3
  • Chemical Name
    1,1'-(((2S,5S,8S,14R)-14-(4-hydroxybenzyl)-8-(naphthalen-2-ylmethyl)-3,6,9,12,15-pentaoxo-1,4,7,10,13-pentaazacyclopentadecane-2,5-diyl)bis(propane-3,1-diyl))diguanidine

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Tamamura H, et al. J Med Chem. 2005 Jan 27;48(2):380-91. 2. Thiele S, et al. Br J Pharmacol. 2014 Dec;171(23):5313-29.
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