Cart
sales@molnova.com
Home - Products - GPCR/G Protein - Chemokine Receptor - GW-766994

GW-766994

CAS No. 408303-43-5

GW-766994( GW766994 )

Catalog No. M14404 CAS No. 408303-43-5

GW-766994 (GW766994) is a potent, selective, orally available CCR3 antagonist.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 268 Get Quote
50MG 1404 Get Quote
100MG 2250 Get Quote
200MG Get Quote Get Quote
500MG Get Quote Get Quote
1G Get Quote Get Quote
Get Quotation Bulk Inquiry Add to Cart

Biological Information

  • Product Name
    GW-766994
  • Note
    Research use only, not for human use.
  • Brief Description
    GW-766994 (GW766994) is a potent, selective, orally available CCR3 antagonist.
  • Description
    GW-766994 (GW766994) is a potent, selective, orally available CCR3 antagonist with pKi of 7.86 for inhibiting eotaxin-induced eosinophil chemotaxis in vitro assays; reverses CCL11-induced activation of CDK5 at 10 uM in rat neurons expressed CCR3, blocks CCL11-induced the production of Aβ and dendritic spine loss in the hippocampal neuronal cultures.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    GW766994
  • Pathway
    GPCR/G Protein
  • Target
    Chemokine Receptor
  • Recptor
    Chemokine Receptor
  • Research Area
    Inflammation/Immunology
  • Indication
    ——

Chemical Information

  • CAS Number
    408303-43-5
  • Formula Weight
    451.348
  • Molecular Formula
    C21H24Cl2N4O3
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO : 56 mg/mL 124.07 mM
  • SMILES
    C1COC(CN1CC2=CC(=C(C=C2)Cl)Cl)CNC(=O)NCC3=CC=C(C=C3)C(=O)N
  • Chemical Name
    (S)-4-((3-((4-(3,4-dichlorobenzyl)morpholin-2-yl)methyl)ureido)methyl)benzamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Neighbour H, et al. Clin Exp Allergy. 2014 Apr;44(4):508-16.
Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog
related products

  • AF-399 42016530

    A potent CCR4 antagonist that blocked CCL22- and CCL17-mediated migration of human peripheral blood CD4+CD25+ Treg and Th2 cells ex-vivo and murine Tregs in-vivo.

  • FC131

    FC131 (cyclo(-D-Tyr-Arg-Arg-Nal-Gly-)) is a selective, cyclopentapeptide CXCR4 antagonist with IC50 of 126 nM.

  • Aplaviroc hydrochlor...

    Aplaviroc (GSK-873140;GW 873140;AK-602;ONO-4128) is a potent, noncompetitive, allosteric antagonist of the CCR5 receptor.

Sign In Join Free