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CCX-354
CAS No. 1010073-75-2
CCX-354( GSK-2941266 | CCX354 | CCX354-C )
Catalog No. M10066 CAS No. 1010073-75-2
CCX-354 (GSK-2941266, CCX354-C, CCX354) is a potent, selective, orally-available CCR1 antagonist for the treatment of inflammatory diseases.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 626 | Get Quote |
|
| 10MG | 888 | Get Quote |
|
| 25MG | 1332 | Get Quote |
|
| 50MG | 1782 | Get Quote |
|
| 100MG | 2250 | Get Quote |
|
| 500MG | 4410 | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameCCX-354
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NoteResearch use only, not for human use.
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Brief DescriptionCCX-354 (GSK-2941266, CCX354-C, CCX354) is a potent, selective, orally-available CCR1 antagonist for the treatment of inflammatory diseases.
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DescriptionCCX-354 (GSK-2941266, CCX354-C, CCX354) is a potent, selective, orally-available CCR1 antagonist for the treatment of inflammatory diseases such as rheumatoid arthritis (RA).Rheumatoid Arthritis Phase 2 Clinical.
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In VitroCCX354 shows potent activities in the chemotaxis assay, with IC50 < 100 nM.
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In VivoIn vivo, CCX354 has in vivo anti-inflammatory activity and has superior pharmacokinetic properties.
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SynonymsGSK-2941266 | CCX354 | CCX354-C
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PathwayGPCR/G Protein
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TargetChemokine Receptor
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RecptorChemokine Receptor
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Research AreaInflammation/Immunology
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IndicationRheumatoid Arthritis
Chemical Information
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CAS Number1010073-75-2
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Formula Weight451.915
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Molecular FormulaC22H22ClN7O2
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (221.28 mM)
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SMILESCOC1=C(C=CC(=C1)N2CCN(CC2)C(=O)CN3C4=C(C=CC=N4)C(=N3)C5=NC=CN5)Cl
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Chemical Name2-(3-(1H-imidazol-2-yl)-1H-pyrazolo[3,4-b]pyridin-1-yl)-1-(4-(4-chloro-3-methoxyphenyl)piperazin-1-yl)ethan-1-one
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Tak PP, et al. Ann Rheum Dis. 2013 Mar;72(3):337-44.
2. Harcken C, et al. Bioorg Med Chem Lett. 2018 Nov 9. pii: S0960-894X(18)30880-1.
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