Exisulind
CAS No. 59973-80-7
Exisulind ( Sulindac sulfone; CP248 )
Catalog No. M27766 CAS No. 59973-80-7
Exisulind induces apoptosis through the activation of protein kinase G (PKG). Exisulind exhibits antineoplastic activity in solid tumour and haematological cancer cell lines and is an inhibitor of tumour growth in rodent models of colon, prostate, bladder, mammary and lung cancer.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
5MG | 42 | Get Quote |
|
10MG | 72 | Get Quote |
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25MG | 147 | Get Quote |
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50MG | 219 | Get Quote |
|
100MG | 323 | Get Quote |
|
200MG | Get Quote | Get Quote |
|
500MG | Get Quote | Get Quote |
|
1G | Get Quote | Get Quote |
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Biological Information
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Product NameExisulind
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NoteResearch use only, not for human use.
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Brief DescriptionExisulind induces apoptosis through the activation of protein kinase G (PKG). Exisulind exhibits antineoplastic activity in solid tumour and haematological cancer cell lines and is an inhibitor of tumour growth in rodent models of colon, prostate, bladder, mammary and lung cancer.
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DescriptionExisulind induces apoptosis through the activation of protein kinase G (PKG). Exisulind exhibits antineoplastic activity in solid tumour and haematological cancer cell lines and is an inhibitor of tumour growth in rodent models of colon, prostate, bladder, mammary and lung cancer.(In Vivo):The topical treatment with NO-Exisulind significantly reduced UVB-induced tumors in SKH-1 hairless mice. The tumors/tumor bearing mouse, the number of tumors/mouse and tumor volume/mouse decreased significantly (P < 0.05) as compared with vehicle-treated and UVB-irradiated positive controls. NO-Exisulind-treated animals showed reduced expression of proliferation markers, such as PCNA and cyclin D1. These mice also manifested increased expression of proapoptotic Bax and decreased expression of antiapoptotic Bcl2 with an increase in the number of TUNEL-positive cells in tumors. NO-Exisulind-treated tumors are less invasive and progress less efficiently from benign to malignant carcinomas.
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SynonymsSulindac sulfone; CP248
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PathwayApoptosis
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TargetApoptosis
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Recptor——
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Research Area——
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Indication——
Chemical Information
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CAS Number59973-80-7
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Formula Weight372.4
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Molecular FormulaC20H17FO4S
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Purity>98% (HPLC)
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Solubility——
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SMILESCC1=C(CC(O)=O)c2cc(F)ccc2\C1=C/c1ccc(cc1)S(C)(=O)=O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Simon L Hill, et al. Clinical toxicology of newer recreational drugs. Clin Toxicol (Phila). 2011 Oct;49(8):705-19.
molnova catalog
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