ASK1-IN-2
CAS No. 2541792-70-3
ASK1-IN-2 ( —— )
Catalog No. M28644 CAS No. 2541792-70-3
ASK1-IN-2 is a potent and orally active inhibitor of apoptosis signal-regulating kinase 1 (ASK1), with an IC50 of 32.8 nM. ASK1-IN-2 can potentially be used as a therapeutic strategy for ulcerative colitis.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
5MG | 192 | Get Quote |
|
10MG | 309 | Get Quote |
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25MG | 525 | Get Quote |
|
50MG | 752 | Get Quote |
|
100MG | 1035 | Get Quote |
|
500MG | 2061 | Get Quote |
|
1G | Get Quote | Get Quote |
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Biological Information
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Product NameASK1-IN-2
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NoteResearch use only, not for human use.
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Brief DescriptionASK1-IN-2 is a potent and orally active inhibitor of apoptosis signal-regulating kinase 1 (ASK1), with an IC50 of 32.8 nM. ASK1-IN-2 can potentially be used as a therapeutic strategy for ulcerative colitis.
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DescriptionASK1-IN-2 is a potent and orally active inhibitor of apoptosis signal-regulating kinase 1 (ASK1), with an IC50 of 32.8 nM. ASK1-IN-2 can potentially be used as a therapeutic strategy for ulcerative colitis.(In Vitro):ASK1-IN-2 displays potent anti-ASK1 kinase activity and strong inhibitory effect on ASK1 in AP1-HEK293 cells with inhibition rate of 95.59%.(In Vivo):ASK1-IN-2 (1 mg/kg; i.v.) shows low clearance (CL=1.38 L/h/kg) and moderate half-life (T1/2=1.45 h) in rats. ASK1-IN-2 (10 mg/kg; p.o.) shows high oral exposure (AUClast=4517 h?ng/mL), 62.2% oral bioavailability and acceptable terminal half-life (T1/2=2.31 h) in rats. ASK1-IN-2 (25 mg/kg; p.o. daily for 7 d) improves dextran sulphate sodium (DSS)-induced ulcerative colitis (UC) in mice. ASK1-IN-2 (25 mg/kg; p.o. daily for 7 d) blocks ASK1-p38/JNK signaling pathways and reduces inflammatory cytokine levels in DSS-induced mouse colon tissues.
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Synonyms——
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PathwayApoptosis
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TargetApoptosis
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RecptorPLK2;PLK3;PLK1
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Research Area——
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Indication——
Chemical Information
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CAS Number2541792-70-3
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Formula Weight364.4
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Molecular FormulaC19H17FN6O
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Purity>98% (HPLC)
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Solubility——
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SMILESCC(C)n1c(-c2cccc(NC(c3cc(ccc(F)c4)c4[nH]3)=O)n2)nnc1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Hanan EJ, et al. Design and synthesis of 2-amino-isoxazolopyridines as Polo-like kinase inhibitors. Bioorg Med Chem Lett. 2008 Oct 1;18(19):5186-9.
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