Batabulin

CAS No. 195533-53-0

Batabulin( T138067 )

Catalog No. M23886 CAS No. 195533-53-0

Batabulin is an antitumor compound, which binds covalently and selectively to a subset of the β-tubulin isotypes, thereby disrupting microtubule polymerization.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 110 In Stock
10MG 160 In Stock
25MG 282 In Stock
50MG 417 In Stock
100MG 601 In Stock
500MG 1242 In Stock
1G Get Quote In Stock

Biological Information

  • Product Name
    Batabulin
  • Note
    Research use only, not for human use.
  • Brief Description
    Batabulin is an antitumor compound, which binds covalently and selectively to a subset of the β-tubulin isotypes, thereby disrupting microtubule polymerization.
  • Description
    Batabulin is an antitumor compound, which binds covalently and selectively to a subset of the β-tubulin isotypes, thereby disrupting microtubule polymerization. Batabulin affects cell morphology and leads to cell-cycle arrest ultimately induce apoptotic cell death.
  • In Vitro
    Cell Cycle Analysis Cell Line:MCF7 cells Concentration:30 nM, 100 nM and 300 nM Incubation Time:24 hours Result:Showed an arrest at the G2/M cell-cycle boundary.Apoptosis Analysis Cell Line:MCF7 cells Concentration:30 nM, 100 nM and 300 nM Incubation Time:24 hours or 48 hours Result:25-30% of cells showed the reduced DNA content characteristic of apoptotic cells.
  • In Vivo
    Animal Model:Male athymic nude mice (nu/nu) (6-8 week-old, 20-25 g) injected with CCRF-CEM cells Dosage:40 mg/kg Administration:Intraperitoneal injection; once per week; on days 5, 12, and 19 Result:Impaired the growth of the drug-sensitive CCRF-CEM tumors.
  • Synonyms
    T138067
  • Pathway
    Apoptosis
  • Target
    Apoptosis
  • Recptor
    Apoptosis|Tubulin β
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    195533-53-0
  • Formula Weight
    371.26
  • Molecular Formula
    C13H7F6NO3S
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:100 mg/mL (269.35 mM; Need ultrasonic)
  • SMILES
    O=S(C1=C(F)C(F)=C(F)C(F)=C1F)(NC2=CC=C(OC)C(F)=C2)=O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Shan B, et al. Selective, covalent modification of beta-tubulin residue Cys-239 by T138067, an antitumor agent with in vivo efficacy against multidrug-resistant tumors. Proc Natl Acad Sci U S A. 1999 May 11;96(10):5686-91.
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