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Exicorilant

CAS No. 1781244-77-6

Exicorilant( CORT125281 | CORT-125281 )

Catalog No. M12679 CAS No. 1781244-77-6

Exicorilant (CORT125281, CORT-125281) is a potent, selective glucocorticoid receptor (GR) antagonist.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Exicorilant
  • Note
    Research use only, not for human use.
  • Brief Description
    Exicorilant (CORT125281, CORT-125281) is a potent, selective glucocorticoid receptor (GR) antagonist.
  • Description
    Exicorilant (CORT125281, CORT-125281) is a potent, selective glucocorticoid receptor (GR) antagonist, exhibits no cross-reactivity for the PR and AR receptors.Prostate Cancer Phase 2 Clinical.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    CORT125281 | CORT-125281
  • Pathway
    Endocrinology/Hormones
  • Target
    GR
  • Recptor
    GR
  • Research Area
    Cancer
  • Indication
    Prostate Cancer

Chemical Information

  • CAS Number
    1781244-77-6
  • Formula Weight
    589.57
  • Molecular Formula
    C26H23F4N7O3S
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    O=C([C@]12CC3=C(N(C4=CC=C(F)C=C4)N=C3)C[C@]1([H])CCN(S(=O)(C5=NN(C)N=C5)=O)C2)C6=NC=CC(C(F)(F)F)=C6
  • Chemical Name
    [(4aR,8aS)-1-(4-fluorophenyl)-6-(2-methyl-2H-1,2,3-triazole-4-sulfonyl)-1,4,5,6,7,8,8a,9-octahydro-4aHpyrazolo[3,4-g]isoquinolin-4a-yl][4-(trifluoromethyl)pyridin2-yl]methanone

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Hunt HJ, et al. J Med Chem. 2017 Apr 27;60(8):3405-3421. 2. Kroon J, et al. Endocrinology. 2018 Jan 1;159(1):535-546.
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