Cart
sales@molnova.com
Home - Products - GPCR/G Protein - Lysophospholipid Receptor - Etrasimod

Etrasimod

CAS No. 1206123-37-6

Etrasimod ( APD334;APD-334;APD 334 )

Catalog No. M10751 CAS No. 1206123-37-6

Etrasimod (APD334) is a potent, selective, centrally available S1P1 receptor antagonist with β-arrestin EC50 of 6.1 nM, internalizes human S1P1 in CHO cells expressing HA tagged S1P1 with IC50 of 1.88 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 61 Get Quote
5MG 104 Get Quote
10MG 172 Get Quote
25MG 332 Get Quote
50MG 500 Get Quote
100MG 628 Get Quote
200MG 895 Get Quote
500MG Get Quote Get Quote
1G Get Quote Get Quote
Group Booking Get Quotation Bulk Inquiry Add to Cart

Biological Information

  • Product Name
    Etrasimod
  • Note
    Research use only, not for human use.
  • Brief Description
    Etrasimod (APD334) is a potent, selective, centrally available S1P1 receptor antagonist with β-arrestin EC50 of 6.1 nM, internalizes human S1P1 in CHO cells expressing HA tagged S1P1 with IC50 of 1.88 nM.
  • Description
    Etrasimod (APD334) is a potent, selective, centrally available S1P1 receptor antagonist with β-arrestin EC50 of 6.1 nM, internalizes human S1P1 in CHO cells expressing HA tagged S1P1 with IC50 of 1.88 nM; produces robust lymphocyte lowering effect (IC50=0.1 uM in mice), shows effectivity in mouse experimental autoimmune encephalomyelitis (EAE) model of MS and a rat collagen induced arthritis (CIA) model, orally active.Irritable Bowel Syndrome Phase 2 Clinical
  • Synonyms
    APD334;APD-334;APD 334
  • Pathway
    GPCR/G Protein
  • Target
    Lysophospholipid Receptor
  • Recptor
    Lysophospholipid Receptor
  • Research Area
    Other Indications
  • Indication
    Irritable Bowel Syndrome

Chemical Information

  • CAS Number
    1206123-37-6
  • Formula Weight
    457.48
  • Molecular Formula
    C26H26F3NO3
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: ≥ 28 mg/mL
  • SMILES
    C1CCC(C1)C2=C(C=C(C=C2)COC3=CC4=C(C=C3)NC5=C4CCC5CC(=O)O)C(F)(F)F
  • Chemical Name
    Cyclopent[b]indole-3-acetic acid, 7-[[4-cyclopentyl-3-(trifluoromethyl)phenyl]methoxy]-1,2,3,4-tetrahydro-, (3R)-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Buzard DJ, et al. ACS Med Chem Lett. 2014 Nov 4;5(12):1313-7.
2. Peyrin-Biroulet L, et al. Autoimmun Rev. 2017 May;16(5):495-503.
3. Nielsen OH, et al. Expert Opin Investig Drugs. 2016 Jun;25(6):709-18.
Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog
related products

  • ASP6432

    ASP6432 (ASP-6432) is a potent and selective antagonist of LPA1 receptor, does-dependently inhibits LPA-stimulated increase in intracellular calcium ion with IC50 of 11 nM.

  • Fingolimod

    An immunomodulatory agent can be phosphorylated by SphK, then functions as a potent agonist of S1P receptors (S1P1/3/4/5) with EC50 of 0.3-5 nM.

  • Ponesimod

    A potent, selective, orally active S1P1 receptor agonist with EC50 of 9.1 nM; shows weak activity on S1P3 (EC50=123 nM).

Sign In Join Free