Enoxolone ( Arthrodont; Biosone; Enoxolone; α-Glycyrrhetinic Acid; GM 1658; NSC 35347; PO 12; STX 352 )

Catalog No. M14567 CAS No. 471-53-4

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Product Name

Enoxolone
Note

Research use only, not for human use.
Brief Description

Enoximone is a selective phosphodiesterase inhibitor with vasodilating and positive inotropic activity that does not cause changes in myocardial oxygen consumption.
Description

Enoximone is a selective phosphodiesterase inhibitor with vasodilating and positive inotropic activity that does not cause changes in myocardial oxygen consumption. It is used in patients with congestive heart failure. Trials were halted in the U.S., but the drug is used in various countries.
Synonyms

Arthrodont; Biosone; Enoxolone; α-Glycyrrhetinic Acid; GM 1658; NSC 35347; PO 12; STX 352
Pathway

Metabolic Enzyme/Protease
Target

Dehydrogenase
Recptor

DHO
Research Area

Other Indications
Indication

——

CAS Number

471-53-4
Formula Weight

470.68
Molecular Formula

C30H46O4
Purity

>98%(HPLC)
Solubility

DMSO: 94 mg/mL (199.71 mM)
SMILES

CC(C)([C@](CC[C@@]([C@@]1(CC[C@]2(CC[C@](C(O)=O)(C[C@]2(C1=C3)[H])C)C)C)4C)5[H])[C@@H](O)CC[C@]5(C)[C@@]4([H])C3=O
Chemical Name

(2S,4aS,6aS,6bR,8aR,10S,12aS,12bR,14bR)-10-hydroxy-2,4a,6a,6b,9,9,12a-heptamethyl-13-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-2-carboxylic acid

1.Boldt J, et al. Expert Opin PharmacOthers. 2007, 8(13):2135-47.

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