Engeletin

Research use only, not for human use.

Engeletin possesses potent inhibition of PGE2 release with IC5 values of 19.6 μg/ml.

Engeletin may serve as a potential anti-inflammatory agent. Engeletin possesses potent inhibition of PGE2 release with IC5 values of 19.6 μg/ml. 3. Engeletin inhibits a recombinant human aldose reductase (IC5 value=1.16 microM).

Engeletin is a flavanonol glycoside isolated from hymenaea martiana, inhibits NF-κB signaling-pathway activation.

Engeletin (25, 50, 100 mg/kg, i.p.) markedly reduces LPS-increased myeloperoxidase activity in mice, activates NF-κB-pathway activation, decreases the production of inflammatory mediators (iNOS and COX-2), and suppresses the expression of TLR4-signaling downstream molecules such as MyD88, IRAK1, TRAF6, and TAK1 proteins.

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Others

Other Targets

Aldose reductase

Inflammation/Immunology

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572-31-6

434.39

C21H22O10

>98% (HPLC)

DMSO : ≥ 83.3 mg/mL; 191.76 mM

CC1C(C(C(C(O1)OC2C(OC3=CC(=CC(=C3C2=O)O)O)C4=CC=C(C=C4)O)O)O)O

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(-20℃)

With Ice Pack

≥ 2 years