Emodepside

Research use only, not for human use.

A semisynthetic derivative of PF1022A, and novel cyclo-depsipeptide anthelmintic which is efficacious against a variety of gastrointestinal nematodes.

A semisynthetic derivative of PF1022A, and novel cyclo-depsipeptide anthelmintic which is efficacious against a variety of gastrointestinal nematodes; causes parasitic nematode muscle relaxation, inhibition of muscle contraction elicited by either ACh or the neuropeptide AF2; elicits a Ca(++)-dependent hyperpolarization of muscle cells.Parasite Infection Phase 1 Clinical

PF 1022-221;PF1022-221;BAY 44-4400;BAY44-4400

Microbiology/Virology

Parasite

Parasite

Infection

Parasite Infection

155030-63-0

1119.39

C60H90N6O14

>98% (HPLC)

DMSO: ≥ 31 mg/mL

O=C([C@H](CC(C)C)N(C)C([C@@H](C)OC([C@H](CC(C)C)N(C)C([C@@H](CC1=CC=C(N2CCOCC2)C=C1)OC([C@H](CC(C)C)N(C)C([C@@H](C)OC([C@H](CC(C)C)N3C)=O)=O)=O)=O)=O)=O)O[C@H](CC4=CC=C(N5CCOCC5)C=C4)C3=O

Cyclo[(αR)-α-hydroxy-4-(4-morpholinyl)benzenepropanoyl-N-methyl-L-leucyl-(2R)-2-hydroxypropanoyl-N-methyl-L-leucyl-(αR)-α-hydroxy-4-(4-morpholinyl)benzenepropanoyl-N-methyl-L-leucyl-(2R)-2-hydroxypropanoyl-N-methyl-L-leucyl]

(-20℃)

With Ice Pack

≥ 2 years