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Efavirenz

CAS No. 154598-52-4

Efavirenz ( DMP 266;EFV;L-743726 )

Catalog No. M12194 CAS No. 154598-52-4

A highly potent nonnucleoside inhibitor (NNRTI) of HIV-1 reverse transcriptase with Ki of 2.93 nM for WT HIV-1 RT.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Efavirenz
  • Note
    Research use only, not for human use.
  • Brief Description
    A highly potent nonnucleoside inhibitor (NNRTI) of HIV-1 reverse transcriptase with Ki of 2.93 nM for WT HIV-1 RT.
  • Description
    A highly potent nonnucleoside inhibitor (NNRTI) of HIV-1 reverse transcriptase with Ki of 2.93 nM for WT HIV-1 RT; inhibits HIV-1 replicative spread in cell culture with IC95 of 1.5 nM; exhibits activity against a panel of NNRTI-resistant mutant viruses; possesses good oral bioavailability and pharmacokinetics; induces autophagy and mitochondrial changes in neurons.HIV Infection Approved
  • Synonyms
    DMP 266;EFV;L-743726
  • Pathway
    Microbiology/Virology
  • Target
    HIV
  • Recptor
    HIV-1RT
  • Research Area
    Infection
  • Indication
    HIV Infection

Chemical Information

  • CAS Number
    154598-52-4
  • Formula Weight
    315.68
  • Molecular Formula
    C14H9ClF3NO2
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: ≥ 38 mg/mL
  • SMILES
    C1CC1C#C[C@]2(C3=C(C=CC(=C3)Cl)NC(=O)O2)C(F)(F)F
  • Chemical Name
    2H-3,1-Benzoxazin-2-one, 6-chloro-4-(2-cyclopropylethynyl)-1,4-dihydro-4-(trifluoromethyl)-, (4S)-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Young SD, et al. Antimicrob Agents Chemother. 1995 Dec;39(12):2602-5.
2. Purnell PR, et al. J Pharmacol Exp Ther. 2014 Nov;351(2):250-8.
3. Bertrand L, et al. Mol Pharmacol. 2015 Aug;88(2):304-15.
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