Efavirenz

Research use only, not for human use.

A highly potent nonnucleoside inhibitor (NNRTI) of HIV-1 reverse transcriptase with Ki of 2.93 nM for WT HIV-1 RT.

A highly potent nonnucleoside inhibitor (NNRTI) of HIV-1 reverse transcriptase with Ki of 2.93 nM for WT HIV-1 RT; inhibits HIV-1 replicative spread in cell culture with IC95 of 1.5 nM; exhibits activity against a panel of NNRTI-resistant mutant viruses; possesses good oral bioavailability and pharmacokinetics; induces autophagy and mitochondrial changes in neurons.HIV Infection Approved

DMP 266;EFV;L-743726

Microbiology/Virology

HIV

HIV-1RT

Infection

HIV Infection

154598-52-4

315.68

C14H9ClF3NO2

>98% (HPLC)

DMSO: ≥ 38 mg/mL

C1CC1C#C[C@]2(C3=C(C=CC(=C3)Cl)NC(=O)O2)C(F)(F)F

2H-3,1-Benzoxazin-2-one, 6-chloro-4-(2-cyclopropylethynyl)-1,4-dihydro-4-(trifluoromethyl)-, (4S)-

(-20℃)

With Ice Pack

≥ 2 years