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CMP-5

CAS No. 880813-42-3

CMP-5 ( PRMT5-IN-5 )

Catalog No. M16388 CAS No. 880813-42-3

CMP-5 (PRMT5-IN-5)is a first-in-class, small-molecule PRMT5-specific inhibitor that blocks EBV-driven B-lymphocyte transformation and survival.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    CMP-5
  • Note
    Research use only, not for human use.
  • Brief Description
    CMP-5 (PRMT5-IN-5)is a first-in-class, small-molecule PRMT5-specific inhibitor that blocks EBV-driven B-lymphocyte transformation and survival.
  • Description
    CMP-5 (PRMT5-IN-5)is a first-in-class, small-molecule PRMT5-specific inhibitor that blocks EBV-driven B-lymphocyte transformation and survival, without effect on normal B cells; displays no activity against other type I (PRMT1 and PRMT4) and type II (PRMT7) enzymes; inhibition of PRMT5 leads to lost recruitment of a PRMT5/p65/HDAC3-repressive complex on the miR96 promoter, restored miR96 expression, and PRMT5 downregulation.
  • Synonyms
    PRMT5-IN-5
  • Pathway
    Chromatin/Epigenetic
  • Target
    HMTase
  • Recptor
    HMTase
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    880813-42-3
  • Formula Weight
    315.42
  • Molecular Formula
    C21H21N3
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    CCN1C2=C(C=C(C=C2)CNCC3=CC=CC=N3)C4=CC=CC=C41.Cl
  • Chemical Name
    1-(9-Ethyl-9H-carbazol-3-yl)-N-(2-pyridinylmethyl)methanamine

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Alinari L, et al. Blood. 2015 Apr 16;125(16):2530-43.
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