EIPA

Research use only, not for human use.

EIPA (L593754, MH 12-43) is a TRPP3 channel inhibitor (IC50: 10.5 μM). It also inhibits Na+/H+-exchanger (NHE) and macropinocytosis.It is found that EIPA, benzamil, and phenamil rapidly and reversibly block Ca2+-activated TRPP3 channel activation at -50 mV, with IC50s of 143, 10.5, 1.1, and 0.14 μM, respectively.

EIPA (L593754, MH 12-43) is a TRPP3 channel inhibitor (IC50: 10.5 μM). It also inhibits Na+/H+-exchanger (NHE) and macropinocytosis.It is found that EIPA, benzamil, and phenamil rapidly and reversibly block Ca2+-activated TRPP3 channel activation at -50 mV, with IC50s of 143, 10.5, 1.1, and 0.14 μM, respectively. The number of autophagic vacuoles increases dramatically in the HAE and HPE groups after EIPA treatment compares with the HAN and HPN groups. EIPA regulates the initiation and maturation of the autophagy associated with amino acids in IEC-18 cells. In addition, the uptake of cinnamoylphenazine (CA-PZ) and neutral red (NR) is inhibited by EIPA.

L593754,MH 12-43

Membrane Transporter/Ion Channel

TRP/TRPV Channel

TRPP3 channel; Na+/H+-exchanger (NHE)

——

——

1154-25-2

299.76

C11H18ClN7O

>98% (HPLC)

DMSO:135 mg/mL (450.36 mM; Need ultrasonic)

CCN(C(C)C)c1nc(N)c(nc1Cl)C(=O)NC(N)=N

——

(-20℃)

With Ice Pack

≥ 2 years