EGFR-IN-8
CAS No. 2407957-87-1
EGFR-IN-8 ( —— )
Catalog No. M26192 CAS No. 2407957-87-1
EGFR-IN-8 can be a promising candidate for further development to target EGFR TKI-resistant NSCLC. EGFR-IN-8 is a dual EGFR and c-Met inhibitor.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
5MG | 259 | Get Quote |
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10MG | 430 | Get Quote |
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25MG | 710 | Get Quote |
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50MG | 972 | Get Quote |
|
100MG | 1332 | Get Quote |
|
200MG | Get Quote | Get Quote |
|
500MG | Get Quote | Get Quote |
|
1G | Get Quote | Get Quote |
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Biological Information
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Product NameEGFR-IN-8
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NoteResearch use only, not for human use.
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Brief DescriptionEGFR-IN-8 can be a promising candidate for further development to target EGFR TKI-resistant NSCLC. EGFR-IN-8 is a dual EGFR and c-Met inhibitor.
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DescriptionEGFR-IN-8 can be a promising candidate for further development to target EGFR TKI-resistant NSCLC. EGFR-IN-8 is a dual EGFR and c-Met inhibitor.(In Vitro):In A549, PC9, H1975, CL68, and CL97?cells, EGFR-IN-8 (0-0.6 μM; 48 hours) suppresses the expression of EGFR and c-Met in these five cell lines irrespective of their mutational status. EGFR-IN-8 (0-20 μM; 24, 48, 72 hours) exhibits a time- and dose-dependent inhibitory effect on the viability of A549, PC9, H1975, CL68, and CL97?cells at different time intervals, with IC50 values ranging from 0.3 to 0.6?μM and 0.2-0.5?μM after 48 and 72?h of treatment respectively.(In Vivo):EGFR-IN-8 (50,150?mg/kg; oral gavage) exhibits suppression (29% and 60%, respectively) of H1975 xenograft tumor growth in a dose-dependent manner.
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Synonyms——
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PathwayAngiogenesis
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TargetEGFR
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Recptor——
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Research Area——
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Indication——
Chemical Information
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CAS Number2407957-87-1
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Formula Weight662.0
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Molecular FormulaC32H23ClF3N7O4
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Purity>98% (HPLC)
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Solubility——
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SMILESFC(F)(F)c1cc(NC(=O)Nc2cccc(c2)-c2nc(no2)-c2ccc(NC(=O)c3cccnc3)cc2Cl)ccc1NC(=O)C1CC1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Chandoga J, et al. Cetaben and fibrates both influence the activities of peroxisomal enzymes in different ways. Biochem Pharmacol. 1994 Feb 9;47(3):515-9.
molnova catalog
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