Cart
sales@molnova.com
BMS-690514
CAS No. 859853-30-8
BMS-690514 ( BMS690514;BMS 690514 )
Catalog No. M16232 CAS No. 859853-30-8
A potent pan HER/VEGFR inhibitor with IC50 of 5/20/60/50 nM for EGFR/HER2/ERBB4/VEGFR2 respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 10MG | 345 | Get Quote |
|
| 100MG | Get Quote | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
-
Product NameBMS-690514
-
NoteResearch use only, not for human use.
-
Brief DescriptionA potent pan HER/VEGFR inhibitor with IC50 of 5/20/60/50 nM for EGFR/HER2/ERBB4/VEGFR2 respectively.
-
DescriptionA potent pan HER/VEGFR inhibitor with IC50 of 5/20/60/50 nM for EGFR/HER2/ERBB4/VEGFR2 respectively; exerts antiproliferative and proapoptotic effects on NSCLC cell lines, with prominent efficacy on H1975 cells expressing the T790M mutation; induces G1 cell cycle arrest.Lung Cancer Phase 2 Discontinued
-
SynonymsBMS690514;BMS 690514
-
PathwayAngiogenesis
-
TargetEGFR
-
RecptorEGFR
-
Research AreaCancer
-
IndicationLung Cancer
Chemical Information
-
CAS Number859853-30-8
-
Formula Weight368.43
-
Molecular FormulaC19H24N6O2
-
Purity>98% (HPLC)
-
Solubility10 mM in DMSO
-
SMILESO[C@@H]1CN(CC2=C3C(NC4=CC=CC(OC)=C4)=NC=NN3C=C2)CC[C@H]1N
-
Chemical Name3-Piperidinol, 4-amino-1-[[4-[(3-methoxyphenyl)amino]pyrrolo[2,1-f][1,2,4]triazin-5-yl]methyl]-, (3R,4R)-
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. de La Motte Rouge T, et al. Cancer Res. 2007 Jul 1;67(13):6253-62.
2. Wong TW, et al. Clin Cancer Res. 2011 Jun 15;17(12):4031-41.
3. Loriot Y, et al. Br J Cancer. 2010 Jul 27;103(3):347-53.
2. Wong TW, et al. Clin Cancer Res. 2011 Jun 15;17(12):4031-41.
3. Loriot Y, et al. Br J Cancer. 2010 Jul 27;103(3):347-53.
molnova catalog
related products
-
Neratinib
A potent, highly selective, irreversible HER2 and EGFR inhibitor with IC50 of 59 nM and 92 nM in cell-free assays.
-
Desmethyl Erlotinib
OSI-420 is the active metabolite of Erlotinib (EGFR inhibitor with IC50 of 2 nM).
-
Ticlopidine
Ticlopidine is an antiplatelet drug in the thienopyridine family which is an adenosine diphosphate (ADP) receptor inhibitor.
