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EF24

CAS No. 342808-40-6

EF24( EF-24 | 3,5-Bis[(2-fluorophenyl)Methylene]-4-piperidinone )

Catalog No. M27874 CAS No. 342808-40-6

EF24 treatment increases the levels of activated caspase 3 and 9, and decreases the phosphorylated forms of MEK1 and ERK.

Purity : >98% (HPLC)

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HNMR

HPLC

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Size	Price / USD	Stock	Quantity
5MG	68	Get Quote
10MG	120	Get Quote
25MG	255	Get Quote
50MG	410	Get Quote
100MG	605	Get Quote
500MG	1287	Get Quote
1G	Get Quote	Get Quote

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Biological Information

Product Name

EF24
Note

Research use only, not for human use.
Brief Description

EF24 treatment increases the levels of activated caspase 3 and 9, and decreases the phosphorylated forms of MEK1 and ERK.
Description

EF24 treatment increases the levels of activated caspase 3 and 9, and decreases the phosphorylated forms of MEK1 and ERK. EF24 shows potent anti-tumor activity in oral squamous cell carcinoma (OSCC) via deactivation of the MAPK/ERK signaling pathway.
In Vitro

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In Vivo

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Synonyms

EF-24 | 3,5-Bis[(2-fluorophenyl)Methylene]-4-piperidinone
Pathway

Apoptosis
Target

PERK
Recptor

——
Research Area

——
Indication

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Chemical Information

CAS Number

342808-40-6
Formula Weight

347.79
Molecular Formula

C19H16ClF2NO
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 50 mg/mL (160.60 mM)
SMILES

Cl.Fc1ccccc1\C=C1/CNC\C(=C/c2ccccc2F)C1=O
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1.Zhang M, et al. A genetically incorporated crosslinker reveals chaperone cooperation in acid resistance. Nat Chem Biol. 2011 Sep 4;7(10):671-7.

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