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DNL343
CAS No. 2278265-85-1
DNL343( —— )
Catalog No. M37220 CAS No. 2278265-85-1
DNL343 is a selective and potent eIF2B activator that crosses the blood-brain barrier and inhibits the assembly of stress granules (SGs) induced by the C9ORF72 dipeptide repeats.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 225 | In Stock |
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| 5MG | 353 | In Stock |
|
| 10MG | 588 | In Stock |
|
| 25MG | 1132 | In Stock |
|
| 50MG | 1822 | In Stock |
|
| 100MG | 2952 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
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Biological Information
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Product NameDNL343
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NoteResearch use only, not for human use.
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Brief DescriptionDNL343 is a selective and potent eIF2B activator that crosses the blood-brain barrier and inhibits the assembly of stress granules (SGs) induced by the C9ORF72 dipeptide repeats.
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DescriptionDNL343 is a brain-penetrating activator of eukaryotic initiation factor 2B (eIF2B) that inhibits the abnormal integrated stress response (ISR). DNL343 inhibits ISR activity in the central nervous system (CNS) and reverses neurodegeneration and neuroinflammation. DNL343 also prevents motor dysfunction and premature death in eIF2B loss-of-function (LOF) mutant mice. DNL343 has inhibitory potential in studies of vanishing white matter disease (VWMD) driven by eIF2B LOF and chronic ISR activation.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayApoptosis
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TargetPERK
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RecptorPERK
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Research Area——
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Indication——
Chemical Information
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CAS Number2278265-85-1
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Formula Weight457.83
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Molecular FormulaC20H19ClF3N3O4
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Purity>98% (HPLC)
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Solubility——
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SMILESN(C(COC1=CC=C(Cl)C=C1)=O)C23CC(C2)(C3)C=4OC(=NN4)[C@@H]5C[C@H](OC(F)(F)F)C5
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Yulyaningsih E, et al. DNL343 is an investigational CNS penetrant eIF2B activator that prevents and reverses the effects of neurodegeneration caused by the Integrated Stress Response[J]. bioRxiv, 2023: 2023.8.21.554203
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