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Home - Products - Chromatin/Epigenetic - Histone Demethylase - E67-2

E67-2

CAS No. 1364914-62-4

E67-2( —— )

Catalog No. M11507 CAS No. 1364914-62-4

E67-2 is a potent and selective inhibitor of H3K9 Jumonji demethylase KIAA1718 (KDM7A) with IC50 of 3.4 uM.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    E67-2
  • Note
    Research use only, not for human use.
  • Brief Description
    E67-2 is a potent and selective inhibitor of H3K9 Jumonji demethylase KIAA1718 (KDM7A) with IC50 of 3.4 uM.
  • Description
    E67-2 is a potent and selective inhibitor of H3K9 Jumonji demethylase KIAA1718 (KDM7A) with IC50 of 3.4 uM; selectively inhibits H3K9 Jumonji demethylase over H3K9 methyltransferase as well as H3K4 demethylase, has low cytotoxicity.
  • In Vitro
    E67-2 (1~100 μM; 5 minutes) reduces inhibitory effect against GLP by a factor of approximately 1500, resulting in an IC50 of 75 μM. E67-2 has much reduced inhibition on PHF8 on the doubly methylated H3(1-24)K4me3K9me2 peptide substrate. E67-2 (100~100000 nM; 24 hours; fibroblasts) has significantly reduced cell toxicity .
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Chromatin/Epigenetic
  • Target
    Histone Demethylase
  • Recptor
    Histone Demethylase
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1364914-62-4
  • Formula Weight
    404.559
  • Molecular Formula
    C21H36N6O2
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    ——
  • Chemical Name
    7-((5-aminopentyl)oxy)-N2-(3-(dimethylamino)propyl)-6-methoxy-N4,N4-dimethylquinazoline-2,4-diamine

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Upadhyay AK, et al. J Mol Biol. 2012 Feb 24;416(3):319-27.
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