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Daminozide

CAS No. 1596-84-5

Daminozide( Alar | Aminozide | B 995 | DIMG | DMASA | Kylar | SADH | Succinic Acid )

Catalog No. M12281 CAS No. 1596-84-5

Daminozide(DMASA; DIMG; B 995), a plant growth regulator, selectively inhibits the KDM2/7 JmjC subfamily.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    Daminozide
  • Note
    Research use only, not for human use.
  • Brief Description
    Daminozide(DMASA; DIMG; B 995), a plant growth regulator, selectively inhibits the KDM2/7 JmjC subfamily.
  • Description
    Daminozide(DMASA; DIMG; B 995), a plant growth regulator, selectively inhibits the KDM2/7 JmjC subfamily.(In Vitro):Daminozide has >100-fold selectivity for KDM2/7 subfamily versus other demethylase subfamily members tested (IC50=127 μM for KDM3A, or greater against other demethylases).(In Vivo):Daminozide (200-20000 ppm) has teratogenic and genotoxic effects on model organism Drosophila melanogaster.
  • In Vitro
    Daminozide has >100-fold selectivity for KDM2/7 subfamily versus other demethylase subfamily members tested (IC50=127 μM for KDM3A, or greater against other demethylases).
  • In Vivo
    Daminozide (200-20000 ppm) has teratogenic and genotoxic effects on model organism Drosophila melanogaster.
  • Synonyms
    Alar | Aminozide | B 995 | DIMG | DMASA | Kylar | SADH | Succinic Acid
  • Pathway
    Chromatin/Epigenetic
  • Target
    Histone Demethylase
  • Recptor
    KDM2/7 JmjC
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    1596-84-5
  • Formula Weight
    160.17
  • Molecular Formula
    C6H12N2O3
  • Purity
    >98% (HPLC)
  • Solubility
    Soluble in DMSO
  • SMILES
    OC(CCC(NN(C)C)=O)=O
  • Chemical Name
    4-(2,2-dimethylhydrazinyl)-4-oxobutanoic acid

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Reed DJ, Moore TC, Anderson JD. Science. 1965 Jun 11;148(3676):1469-71.
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