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Dolasetron

CAS No. 115956-12-2

Dolasetron( HSDB 7565 | HSDB7565 | Dolasetron | Dolasetronum )

Catalog No. M17847 CAS No. 115956-12-2

Dolasetron(MDL-73147) is a serotonin 5-HT3 receptor antagonist used to treat nausea and vomiting following chemotherapy.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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2MG 40 In Stock
5MG 65 In Stock
10MG 98 In Stock
25MG 177 In Stock
50MG 295 In Stock
100MG 444 In Stock
500MG 963 In Stock
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Biological Information

  • Product Name
    Dolasetron
  • Note
    Research use only, not for human use.
  • Brief Description
    Dolasetron(MDL-73147) is a serotonin 5-HT3 receptor antagonist used to treat nausea and vomiting following chemotherapy.
  • Description
    Dolasetron is a serotonin 5-HT3 receptor antagonist used to treat nausea and vomiting following chemotherapy. Its main effect is to reduce the activity of the vagus nerve, which is a nerve that activates the vomiting center in the medulla oblongata. It does not have much antiemetic effect when symptoms are due to motion sickness. This drug does not have any effect on dopamine receptors or muscarinic receptors.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    HSDB 7565 | HSDB7565 | Dolasetron | Dolasetronum
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    5-HT3
  • Research Area
    Others-Field
  • Indication
    ——

Chemical Information

  • CAS Number
    115956-12-2
  • Formula Weight
    324.38
  • Molecular Formula
    C19H20N2O3
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO : ≥ 300 mg/mL; 924.87 mM
  • SMILES
    [H][C@]12C[C@@H](C[C@@H]3C[C@H](C1)C(=O)CN23)OC(=O)c1c[nH]c2ccccc12
  • Chemical Name
    (6R)-3-oxooctahydro-1H-2,6-methanoquinolizin-8-yl 1H-indole-3-carboxylate

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Faria C,etal.Outcomes Associated with 5-HT3-RA Therapy Selection in Patients with Chemotherapy-Induced Nausea and Vomiting: A Retrospective Claims Analysis.Am Health Drug Benefits. 2014 Jan;7(1):50-8.
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