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Lats-IN-1

CAS No. 1424635-83-5

Lats-IN-1( —— )

Catalog No. M23576 CAS No. 1424635-83-5

Lats-IN-1 is a potent and ATP-competitive Lats1 and Lats2 kinases inhibitor. It promotes Yap-dependent proliferation in postmitotic mammalian tissues.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 133 In Stock
10MG 209 In Stock
25MG 415 In Stock
50MG 536 In Stock
100MG 763 In Stock
200MG 1053 In Stock
500MG Get Quote In Stock
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Biological Information

  • Product Name
    Lats-IN-1
  • Note
    Research use only, not for human use.
  • Brief Description
    Lats-IN-1 is a potent and ATP-competitive Lats1 and Lats2 kinases inhibitor. It promotes Yap-dependent proliferation in postmitotic mammalian tissues.
  • Description
    Lats-IN-1 is a potent and ATP-competitive Lats1 and Lats2 kinases inhibitor. It promotes Yap-dependent proliferation in postmitotic mammalian tissues.
  • In Vitro
    Cell Proliferation Assay Cell Line:MCF 10A cells Concentration:10 μM Incubation Time:24 hours Result:Decreased the phosphorylation of Yap at residue S127.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Lats1|Lats2
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1424635-83-5
  • Formula Weight
    334.39
  • Molecular Formula
    C18H14N4OS
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:83.33 mg/mL (249.20 mM; Need ultrasonic)
  • SMILES
    O=C(C1=CNC2=NC=CC=C12)/N=C(SC=C3)/N3CC4=CC=CC=C4
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Nathaniel Kastan, et al. Small-molecule inhibition of Lats kinases promotes Yap-dependent proliferation in postmitotic mammalian tissues. bioRxiv 2020.02.11.944157.
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