Dofequidar

CAS No. 129716-58-1

Dofequidar ( MS-209 )

Catalog No. M11198 CAS No. 129716-58-1

A novel, orally active quinoline compound that can reverse P-glycoprotein (P-gp)-mediated MDR.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 873 Get Quote
50MG 1782 Get Quote
100MG 2250 Get Quote
200MG Get Quote Get Quote
500MG Get Quote Get Quote
1G Get Quote Get Quote

Biological Information

  • Product Name
    Dofequidar
  • Note
    Research use only, not for human use.
  • Brief Description
    A novel, orally active quinoline compound that can reverse P-glycoprotein (P-gp)-mediated MDR.
  • Description
    A novel, orally active quinoline compound that can reverse P-glycoprotein (P-gp)-mediated MDR; completely reverses resistance against vincristine in vitro in multidrug-resistant variants of mouse leukemia P388 cells and human leukemia K562 cells at 1-10 uM; greatly reduces the SP-derived tumor growth in vivo combined with CPT-11.Breast cancer Phase 2 Discontinued
  • Synonyms
    MS-209
  • Pathway
    Membrane Transporter/Ion Channel
  • Target
    P-glycoprotein
  • Recptor
    P-glycoprotein
  • Research Area
    Cancer
  • Indication
    Breast Cancer

Chemical Information

  • CAS Number
    129716-58-1
  • Formula Weight
    481.59
  • Molecular Formula
    C30H31N3O3
  • Purity
    >98% (HPLC)
  • Solubility
    10 mM in DMSO
  • SMILES
    C1CN(CCN1CC(COC2=CC=CC3=C2C=CC=N3)O)C(=O)C(C4=CC=CC=C4)C5=CC=CC=C5
  • Chemical Name
    Ethanone, 1-[4-[2-hydroxy-3-(5-quinolinyloxy)propyl]-1-piperazinyl]-2,2-diphenyl-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Nakanishi O, et al. Oncol Res. 1997;9(2):61-9.
2. Sato W, et al. Cancer Chemother Pharmacol. 1995;35(4):271-7.
3. Katayama R, et al. Cancer Sci. 2009 Nov;100(11):2060-8.
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