Dofequidar ( MS-209 )

Catalog No. M11198 CAS No. 129716-58-1

A novel, orally active quinoline compound that can reverse P-glycoprotein (P-gp)-mediated MDR.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

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50MG	1782	Get Quote
100MG	2250	Get Quote
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Biological Information

Product Name

Dofequidar
Note

Research use only, not for human use.
Brief Description

A novel, orally active quinoline compound that can reverse P-glycoprotein (P-gp)-mediated MDR.
Description

A novel, orally active quinoline compound that can reverse P-glycoprotein (P-gp)-mediated MDR; completely reverses resistance against vincristine in vitro in multidrug-resistant variants of mouse leukemia P388 cells and human leukemia K562 cells at 1-10 uM; greatly reduces the SP-derived tumor growth in vivo combined with CPT-11.Breast cancer Phase 2 Discontinued
Synonyms

MS-209
Pathway

Membrane Transporter/Ion Channel
Target

P-glycoprotein
Recptor

P-glycoprotein
Research Area

Cancer
Indication

Breast Cancer

Chemical Information

CAS Number

129716-58-1
Formula Weight

481.59
Molecular Formula

C30H31N3O3
Purity

>98% (HPLC)
Solubility

10 mM in DMSO
SMILES

C1CN(CCN1CC(COC2=CC=CC3=C2C=CC=N3)O)C(=O)C(C4=CC=CC=C4)C5=CC=CC=C5
Chemical Name

Ethanone, 1-[4-[2-hydroxy-3-(5-quinolinyloxy)propyl]-1-piperazinyl]-2,2-diphenyl-

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Nakanishi O, et al. Oncol Res. 1997;9(2):61-9.
2. Sato W, et al. Cancer Chemother Pharmacol. 1995;35(4):271-7.
3. Katayama R, et al. Cancer Sci. 2009 Nov;100(11):2060-8.

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