Tariquidar

CAS No. 206873-63-4

Tariquidar ( XR 9576;XR-9576;XR9576 )

Catalog No. M13215 CAS No. 206873-63-4

A potent, specific P-gp inhibitor with Kd of 5.1 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 41 In Stock
10MG 69 In Stock
25MG 119 In Stock
50MG 215 In Stock
100MG 361 In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
1G Get Quote In Stock

Biological Information

  • Product Name
    Tariquidar
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent, specific P-gp inhibitor with Kd of 5.1 nM.
  • Description
    A potent, specific P-gp inhibitor with Kd of 5.1 nM; potentiates the cytotoxicity of several drugs including doxorubicin, paclitaxel, etoposide, and vincristine in a panel of human MDR cell lines at 25-80 nM; exhibits potent i.v. and p.o. activity without apparently enhancing the plasma pharmacokinetics of paclitaxel or the toxicity of coadministered drugs.Breast Cancer Phase 2 Discontinued
  • Synonyms
    XR 9576;XR-9576;XR9576
  • Pathway
    Membrane Transporter/Ion Channel
  • Target
    P-glycoprotein
  • Recptor
    P-gp(P-glycoprotein)
  • Research Area
    Cancer
  • Indication
    Breast Cancer

Chemical Information

  • CAS Number
    206873-63-4
  • Formula Weight
    646.73
  • Molecular Formula
    C38H38N4O6
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: ≥ 100 mg/mL
  • SMILES
    COC1=CC2=C(CN(CCC3=CC=C(NC(=O)C4=C(NC(=O)C5=CC6=CC=CC=C6N=C5)C=C(OC)C(OC)=C4)C=C3)CC2)C=C1OC |c:17,26,28,31,40,43,49,t:2,4,10,12,22,24,34|
  • Chemical Name
    3-Quinolinecarboxamide, N-[2-[[[4-[2-(3,4-dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)ethyl]phenyl]amino]carbonyl]-4,5-dimethoxyphenyl]-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Martin C, et al. Br J Pharmacol. 1999 Sep;128(2):403-11.
2. Mistry P, et al. Cancer Res. 2001 Jan 15;61(2):749-58.
3. Walker J, et al. Eur J Cancer. 2004 Mar;40(4):594-605.
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