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Disarib
CAS No. 1998149-15-7
Disarib( —— )
Catalog No. M13120 CAS No. 1998149-15-7
Disarib is a novel BCL2-specific inhibitor that binds predominantly to the BH1 domain.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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| 100MG | Get Quote | Get Quote |
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Biological Information
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Product NameDisarib
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NoteResearch use only, not for human use.
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Brief DescriptionDisarib is a novel BCL2-specific inhibitor that binds predominantly to the BH1 domain.
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DescriptionDisarib is a novel BCL2-specific inhibitor that binds predominantly to the BH1 domain, demonstrates strong affinity to BCL2, but not to other antiapoptotic BCL2 family members(BCL-xL, BCL2A1 etc.); is a novel BCL2 inhibitor with a unique mechanism of BCL2 inhibition.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayAngiogenesis
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TargetBcl-2
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RecptorBcl-2
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Research Area——
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Indication——
Chemical Information
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CAS Number1998149-15-7
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Formula Weight547.855
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Molecular FormulaC26H16BrClN4OS
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Purity>98% (HPLC)
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Solubility——
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SMILES——
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Chemical Name3-((2-(4-chlorobenzyl)-6-(4-bromophenyl)imidazo[2,1-b][1,3,4] -thiadiazol-5-yl)methylidene)-1,3-dihydro-2H-indol-2-one
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Iyer D, et al. FEBS J. 2016 Sep;283(18):3408-37.
2. Vartak SV, et al. Biochem Pharmacol. 2016 Dec 15;122:10-22.
3. Vartak SV, et al. Biochem Pharmacol. 2017 May 1;131:16-28. doi:
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