BM-957 ( BM957 )

Catalog No. M11619 CAS No. 1391107-54-2

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

BM-957
Note

Research use only, not for human use.
Brief Description

BM-957 is a highly potent, dual Bcl-2 and Bcl-xL inhibitor with Ki of <1 nM for both, IC50 of 5.4 and 6.0 nM, respectively.
Description

BM-957 is a highly potent, dual Bcl-2 and Bcl-xL inhibitor with Ki of <1 nM for both, IC50 of 5.4 and 6.0 nM, respectively; shows potent cell growth inhibition in cancer cell lines, with IC50 of ~20 nM against the H1147 and H146 cells; induces robust cleavage of PARP and caspase-3 at 10 nM in the H146 cell line, achieves complete and durable tumor regression in H146 xenograft tumors.
Synonyms

BM957
Pathway

Angiogenesis
Target

Bcl-2
Recptor

Bcl-2
Research Area

——
Indication

——

CAS Number

1391107-54-2
Formula Weight

1065.68
Molecular Formula

C52H56ClF3N6O7S3
Purity

>98% (HPLC)
Solubility

——
SMILES

O=C(C1=C(C)N(CC)C(C2=CC=C(Cl)C=C2)=C1C3=CC=CC(N4CCN(C5=CC=C(NS(=O)(C6=CC=C(N[C@H](CCN7CCC(O)CC7)CSC8=CC=CC=C8)C(S(=O)(C(F)(F)F)=O)=C6)=O)C=C5)CC4)=C3)O
Chemical Name

(R)-5-(4-Chlorophenyl)-1-ethyl-4-(3-(4-(4-(4-(4-(4-hydroxypiperidin-1-yl)-1-(phenylthio) butan-2-ylamino)-3-(trifluoromethylsulfonyl)phenylsulfonamido)phenyl)piperazin-1-yl) phenyl)-2-methyl-1H-pyrrole-3-carboxylic Acid

1. Chen J, et al. J Med Chem. 2012 Oct 11;55(19):8502-14.

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