BI-3802 ( BI3802;BI 3802 )

Catalog No. M13459 CAS No. 2166387-65-9

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Datasheet

HNMR

HPLC

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Product Name

BI-3802
Note

Research use only, not for human use.
Brief Description

BI-3802 (BI3802) is a highly potent and efficacious BCL6 degrader that potently inhibits the interaction of the BTB/POZ domain of BCL6 with several co-repressors in vitro with IC50 of <3 nM.
Description

BI-3802 (BI3802) is a highly potent and efficacious BCL6 degrader that potently inhibits the interaction of the BTB/POZ domain of BCL6 with several co-repressors in vitro with IC50 of <3 nM; inhibits the BCL6/Co-repressor complex formation with IC50 of 43 nM in vitro, also is a potent and efficacious degrader of the BCL6 protein in many DLBCL cell lines (DC50=20 nM in SU-DHL-4 cells); BI-3802 is a valuable probe compound for testing hypotheses around BCL6 biology.
Synonyms

BI3802;BI 3802
Pathway

Angiogenesis
Target

Bcl-2
Recptor

Bcl-2
Research Area

Cancer
Indication

——

CAS Number

2166387-65-9
Formula Weight

484.99
Molecular Formula

C24H29ClN6O3
Purity

>98% (HPLC)
Solubility

DMSO : 5 mg/mL 10.31 mM; Methanol : 2 mg/mL 4.12 mM; H2O : < 0.1 mg/mL
SMILES

O=C(NC)COC1=CC2=C(N(C)C1=O)C=CC(NC3=NC(N4C[C@@H](C)C[C@@H](C)C4)=NC=C3Cl)=C2
Chemical Name

2-((6-((5-chloro-2-((3S,5R)-3,5-dimethylpiperidin-1-yl)pyrimidin-4-yl)amino)-1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)oxy)-N-methylacetamide

1. Kerres N, et al. Cell Rep. 2017 Sep 19;20(12):2860-2875.

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