BI-3802

Research use only, not for human use.

BI-3802 (BI3802) is a highly potent and efficacious BCL6 degrader that potently inhibits the interaction of the BTB/POZ domain of BCL6 with several co-repressors in vitro with IC50 of <3 nM.

BI-3802 (BI3802) is a highly potent and efficacious BCL6 degrader that potently inhibits the interaction of the BTB/POZ domain of BCL6 with several co-repressors in vitro with IC50 of <3 nM; inhibits the BCL6/Co-repressor complex formation with IC50 of 43 nM in vitro, also is a potent and efficacious degrader of the BCL6 protein in many DLBCL cell lines (DC50=20 nM in SU-DHL-4 cells); BI-3802 is a valuable probe compound for testing hypotheses around BCL6 biology.

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BI3802 | BI 3802

Angiogenesis

Bcl-2

Bcl-2

Cancer

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2166387-65-9

484.985

C24H29ClN6O3

>98% (HPLC)

DMSO : 5 mg/mL 10.31 mM; Methanol : 2 mg/mL 4.12 mM; H2O : < 0.1 mg/mL

O=C(NC)COC1=CC2=C(N(C)C1=O)C=CC(NC3=NC(N4C[C@@H](C)C[C@@H](C)C4)=NC=C3Cl)=C2

2-((6-((5-chloro-2-((3S,5R)-3,5-dimethylpiperidin-1-yl)pyrimidin-4-yl)amino)-1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)oxy)-N-methylacetamide

(-20℃)

With Ice Pack

≥ 2 years