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Home - Research Areas - Cancer - Brain Cancer - Diazepinomicin

Diazepinomicin

CAS No. 733035-26-2

Diazepinomicin( TLN 4601 | ECO-4601 )

Catalog No. M15806 CAS No. 733035-26-2

Diazepinomicin (TLN 4601, ECO-4601) is a brain penetrant inhibitor of Ras-RAF-MAPK pathway post Ras prenylation and prior to MEK activation.

Diazepinomicin (TLN 4601, ECO-4601) is a brain penetrant inhibitor of Ras-RAF-MAPK pathway post Ras prenylation and prior to MEK activation.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    Diazepinomicin
  • Note
    Research use only, not for human use.
  • Brief Description
    Diazepinomicin (TLN 4601, ECO-4601) is a brain penetrant inhibitor of Ras-RAF-MAPK pathway post Ras prenylation and prior to MEK activation.
  • Description
    Diazepinomicin (TLN 4601, ECO-4601) is a brain penetrant inhibitor of Ras-RAF-MAPK pathway post Ras prenylation and prior to MEK activation, binds the central and/or peripheral benzodiazepine receptors (PBR, TSPO); prevents EGF-induced phosphorylation of Raf-1, MEK, and ERK1/2; reduces Ras-GTP levels and induces apoptosis; shows antitumor activity and decreases tumor Raf-1 protein levels in MIA PaCa-2 tumor-bearing mice.Brain Cancer Phase 2 Discontinued.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    TLN 4601 | ECO-4601
  • Pathway
    Cancer
  • Target
    Brain Cancer
  • Recptor
    TSPO
  • Research Area
    Cancer
  • Indication
    Brain Cancer

Chemical Information

  • CAS Number
    733035-26-2
  • Formula Weight
    462.58
  • Molecular Formula
    C28H34N2O4
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    O=C1C2=CC=CC(O)=C2NC3=C(O)C=C(O)C=C3N1C/C=C(C)/CC/C=C(C)/CC/C=C(C)\C
  • Chemical Name
    4,6,8-trihydroxy-10-((2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl)-5H-dibenzo[b,e][1,4]diazepin-11(10H)-one

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Campbell PM, et al. J Mol Signal. 2010 Nov 2;5:18. 2. Quah SY, et al. Pharmacol Ther. 2016 Jun;162:35-57. 3. Boufaied N, et al. Anticancer Drugs. 2010 Jun;21(5):543-52.
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