Deflazacort( DL-458IT | L-5,458 | MDL 458 )

Catalog No. M11921 CAS No. 14484-47-0

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Datasheet

HNMR

HPLC

MSDS

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Product Name

Deflazacort
Note

Research use only, not for human use.
Brief Description

Deflazacort is a glucocorticoid used as an anti-inflammatory and immunosuppressant.
Description

Deflazacort is a glucocorticoid used as an anti-inflammatory and immunosuppressant.It suppresses the immune system and so it can be used to treat autoimmune diseases. Deflazacort can help to prevent and to treat the rejection of transplanted organs. It can also be used in the treatment of certain types of Ys. (In Vitro):Deflazacort is an inactive prodrug which is converted rapidly to the active metabolite 21-desacetyldeflazacort. Maximum concentrations of 21-desacetyldeflazacort averaged 116 ng/ml and were observed after 1.3 h. The average area under the curve was 280 ng/ml.h, and the terminal half-life was 1.3 h. 21-Desacetyldeflazacort was cleared significantly faster than both methylprednisolone and prednisolone.
In Vitro

——
In Vivo

——
Synonyms

DL-458IT | L-5,458 | MDL 458
Pathway

Endocrinology/Hormones
Target

GR
Recptor

Glucocorticoid Receptor
Research Area

Inflammation/Immunology
Indication

——

CAS Number

14484-47-0
Formula Weight

441.53
Molecular Formula

C25H31NO6
Purity

>98% (HPLC)
Solubility

Ethanol: 12 mg/mL (27.17 mM); DMSO: 88 mg/mL (199.31 mM)
SMILES

CC(OCC(C12N=C(C)OC1CC3C(CCC4=CC(C=C[C@@]45C)=O)C5[C@@H](O)C[C@@]32C)=O)=O
Chemical Name

2-((6aR,7S,8aS)-7-hydroxy-6a,8a,10-trimethyl-4-oxo-2,4,6a,6b,7,8,8a,8b,11a,12,12a,12b-dodecahydro-1H-naphtho[2',1':4,5]indeno[1,2-d]oxazol-8b-yl)-2-oxoethyl acetate

1.Walter MC, et al. Orphanet J Rare Dis. 2013 Feb 14;8:26.

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