AZD-7594

CAS No. 1196509-60-0

AZD-7594( AZ-13189620 )

Catalog No. M10693 CAS No. 1196509-60-0

AZD-7594 (AZ-13189620) is a potent, nonsteroidal, selective glucocorticoid receptor modulator (SGRM) with binding IC50 of 0.9 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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5MG 115 Get Quote
10MG 160 Get Quote
25MG 356 Get Quote
50MG 530 Get Quote
100MG 759 Get Quote
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Biological Information

  • Product Name
    AZD-7594
  • Note
    Research use only, not for human use.
  • Brief Description
    AZD-7594 (AZ-13189620) is a potent, nonsteroidal, selective glucocorticoid receptor modulator (SGRM) with binding IC50 of 0.9 nM.
  • Description
    AZD-7594 (AZ-13189620) is a potent, nonsteroidal, selective glucocorticoid receptor modulator (SGRM) with binding IC50 of 0.9 nM, shows no affinity for AR, PR, MR and ERα/β; demonstrates cell potentcy with IC50 of 55 nM (repression of AP-1 dependent transcription), inhibits LPS-stimulated TNF-α production in human PBMC with IC50 0.43 nM; potently inhibits lung edema in a rat model of allergic airway inflammation with inhaled EC50 of 130 uM/Kg.Asthma Phase 2 Clinical(In Vitro):AZD7594 is a potent selective nonsteroidal glucocorticoid receptor modulator, with an IC50 of 0.9 nM. AZD7594 shows no effect on progesterone receptor, mineralocorticoid receptor, Androgen receptor, ERα or ERβ (IC50, > 10 μM).(In Vivo):AZD7594 has anti-inflammatory activity, and efficiently inhibits rat lung edema.
  • In Vitro
    AZD7594 is a potent selective nonsteroidal glucocorticoid receptor modulator, with an IC50 of 0.9 nM. AZD7594 shows no effect on progesterone receptor, mineralocorticoid receptor, Androgen receptor, ERα or ERβ (IC50, > 10 μM).
  • In Vivo
    AZD7594 has anti-inflammatory activity, and efficiently inhibits rat lung edema.
  • Synonyms
    AZ-13189620
  • Pathway
    Endocrinology/Hormones
  • Target
    GR
  • Recptor
    GR
  • Research Area
    Inflammation/Immunology
  • Indication
    Asthma

Chemical Information

  • CAS Number
    1196509-60-0
  • Formula Weight
    606.627
  • Molecular Formula
    C32H32F2N4O6
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO : ≥ 83.3 mg/mL137.32 mM
  • SMILES
    O=C(NC1COCC1)C2=CC=CC(N3N=CC4=C3C=CC(O[C@H](C5=CC=C(OCCO6)C6=C5)[C@@H](NC(C(F)(F)C)=O)C)=C4)=C2
  • Chemical Name
    3-(5-((1R,2S)-2-(2,2-difluoropropanamido)-1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)propoxy)-1H-indazol-1-yl)-N-((R)-tetrahydrofuran-3-yl)benzamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Hemmerling M, et al. J Med Chem. 2017 Oct 26;60(20):8591-8605.
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