
Decanoyl-RVKR-CMK
CAS No. 150113-99-8
Decanoyl-RVKR-CMK( —— )
Catalog No. M30696 CAS No. 150113-99-8
Subtilisin/Kex2p-like proprotein convertase inhibitor; blocks activity of all seven convertases (PC1, PC2, PC4, PACE4, PC5, PC7 and furin). Abolishes proET-1 processing in endothelial cells; inhibits regulated secretion of the neuronal polypeptide VGF in PC12 cells.
Purity : >98% (HPLC)






Size | Price / USD | Stock | Quantity |
10MG | 573 | Get Quote |
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100MG | Get Quote | Get Quote |
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200MG | Get Quote | Get Quote |
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500MG | Get Quote | Get Quote |
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Biological Information
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Product NameDecanoyl-RVKR-CMK
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NoteResearch use only, not for human use.
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Brief DescriptionSubtilisin/Kex2p-like proprotein convertase inhibitor; blocks activity of all seven convertases (PC1, PC2, PC4, PACE4, PC5, PC7 and furin). Abolishes proET-1 processing in endothelial cells; inhibits regulated secretion of the neuronal polypeptide VGF in PC12 cells.
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DescriptionSubtilisin/Kex2p-like proprotein convertase inhibitor; blocks activity of all seven convertases (PC1, PC2, PC4, PACE4, PC5, PC7 and furin). Abolishes proET-1 processing in endothelial cells; inhibits regulated secretion of the neuronal polypeptide VGF in PC12 cells.
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In VitroDecanoyl-RVKR-CMK (DecRVKRcmk) inhibits HIV-2ROD replication by blocking envelope glycoprotein precursor processing in the Jurkat lymphocyte cell.Decanoyl-RVKR-CMK (DecRVKRcmk) blocks regulated secretion of VGF. Cell Viability Assay Cell Line:HeLaCD4 cells infected with recombinant vaccinia viruses at a multiplicity of infection (MOI) of 5 PFU/mL.Concentration:35 and 70 μΜ.Incubation Time:7 days.Result:Peptide at 35 μM significantly inhibited ex vivo HIV-1 and HIV-2 replications (70-80% inhibition).
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In Vivo——
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Synonyms——
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PathwayMicrobiology/Virology
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TargetHIV
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Recptor——
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Research Area——
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Indication——
Chemical Information
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CAS Number150113-99-8
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Formula Weight744.42
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Molecular FormulaC34H66ClN11O5
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Purity>98% (HPLC)
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Solubilitywater:1 mg/mL
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SMILES[H]N([C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)CCl)C(=O)CCCCCCCCC
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Garcia et al (2005) A prohormone convertase cleavage site within a predicted alpha-helix mediates sorting of the neuronal and endocrine polypeptide VGF into the regulated secretory pathway. J.Biol.Chem. 280 41595 PMID:
molnova catalog



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