Decanoyl-RVKR-CMK

Research use only, not for human use.

Subtilisin/Kex2p-like proprotein convertase inhibitor; blocks activity of all seven convertases (PC1, PC2, PC4, PACE4, PC5, PC7 and furin). Abolishes proET-1 processing in endothelial cells; inhibits regulated secretion of the neuronal polypeptide VGF in PC12 cells.

Subtilisin/Kex2p-like proprotein convertase inhibitor; blocks activity of all seven convertases (PC1, PC2, PC4, PACE4, PC5, PC7 and furin). Abolishes proET-1 processing in endothelial cells; inhibits regulated secretion of the neuronal polypeptide VGF in PC12 cells.

Decanoyl-RVKR-CMK (DecRVKRcmk) inhibits HIV-2ROD replication by blocking envelope glycoprotein precursor processing in the Jurkat lymphocyte cell.Decanoyl-RVKR-CMK (DecRVKRcmk) blocks regulated secretion of VGF. Cell Viability Assay Cell Line:HeLaCD4 cells infected with recombinant vaccinia viruses at a multiplicity of infection (MOI) of 5 PFU/mL.Concentration:35 and 70 μΜ.Incubation Time:7 days.Result:Peptide at 35 μM significantly inhibited ex vivo HIV-1 and HIV-2 replications (70-80% inhibition).

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Microbiology/Virology

HIV

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150113-99-8

744.42

C34H66ClN11O5

>98% (HPLC)

water:1 mg/mL

[H]N([C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)CCl)C(=O)CCCCCCCCC

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(-20℃)

With Ice Pack

≥ 2 years